{"id":"W4396951730","doi":"10.3390/cells13100849","title":"Induced Pluripotent Stem Cell-Derived Fibroblasts Efficiently Engage Senescence Pathways but Show Increased Sensitivity to Stress Inducers","year":2024,"lang":"en","type":"article","venue":"Cells","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Senescence; Inducer; Cell biology; Induced pluripotent stem cell; Cellular senescence; Stem cell; Sensitivity (control systems); Biology; Cell survival; Cell; Chemistry; Cell culture; Embryonic stem cell; Genetics; Phenotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005557222,0.0005490234,0.0006560095,0.0003884133,0.0002228313,0.0001695061,0.000218909,0.0002900309,0.00009039572],"category_scores_gemma":[0.00007730931,0.0005005461,0.0002376882,0.0008238397,0.0001116527,0.0001592504,0.000192981,0.0008238915,0.0005428349],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003143187,"about_ca_system_score_gemma":0.0005093325,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005367632,"about_ca_topic_score_gemma":0.00006981448,"domain_scores_codex":[0.9963537,0.0003594007,0.0005172897,0.001117788,0.0007816196,0.0008701317],"domain_scores_gemma":[0.997543,0.0004779385,0.00009599972,0.0008121925,0.00019267,0.0008782033],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001817346,0.0002884831,0.0005302978,0.0007324374,0.00005307304,0.002049168,0.003026693,0.0001556676,0.9784055,0.00001160057,0.0005461273,0.01401918],"study_design_scores_gemma":[0.0008064017,0.0003618536,0.00642259,0.001121823,0.0001047073,0.00007921275,0.002574398,0.002570814,0.9844114,0.000002287701,0.0009882236,0.0005563291],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948914,0.000324924,0.0009420827,0.0003279009,0.001158188,0.001100906,0.00022374,0.0005314853,0.0004993631],"genre_scores_gemma":[0.9974633,0.00004375361,0.00046999,0.0006386113,0.0003623191,0.00003076015,0.00005727402,0.00009837135,0.000835587],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01346285,"threshold_uncertainty_score":0.9997446,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02409161423262934,"score_gpt":0.2364818169531424,"score_spread":0.2123902027205131,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}