{"id":"W4396957290","doi":"10.1097/js9.0000000000001609","title":"Recent advances in stem cell therapy: efficacy, ethics, safety concerns, and future directions focusing on neurodegenerative disorders – a review","year":2024,"lang":"en","type":"review","venue":"International Journal of Surgery","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Global Health Research","funders":"","keywords":"Stem cell; Neurodegeneration; Medicine; Growth factor; Remyelination; Neuroscience; Keratinocyte growth factor; Stem-cell therapy; Myelin; Cell biology; Cancer research; Biology; Pathology; Disease; Internal medicine; Central nervous system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001542986,0.0007333457,0.001281547,0.002009703,0.0003357554,0.001712542,0.0008502335,0.001512436,0.003413906],"category_scores_gemma":[0.001721175,0.0002438933,0.0006162396,0.002201666,0.0007945926,0.002053509,0.0007797839,0.001824273,0.001159683],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005889522,"about_ca_system_score_gemma":0.001252836,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000652643,"about_ca_topic_score_gemma":0.0009462928,"domain_scores_codex":[0.9995964,0.00008423917,0.0000775222,0.00007129009,0.0001376457,0.00003291528],"domain_scores_gemma":[0.9982489,0.001169702,0.0001426145,0.00003375832,0.0003138448,0.00009126664],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001111355,0.00008162414,0.0002358724,0.01799807,0.00006683394,0.0002118765,0.000129473,0.0003176734,0.001812943,0.005261928,0.02809891,0.9456737],"study_design_scores_gemma":[0.00002121801,0.0002214453,0.0007417727,0.005592025,0.0001741734,0.001418063,0.0001797543,0.0001554462,0.001056259,0.003764436,0.9866432,0.00003223908],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001611146,0.9982405,0.0001716672,0.000556993,0.0003019342,0.000004091317,0.00001180971,0.000005957772,0.0005460058],"genre_scores_gemma":[0.0008121571,0.9977214,0.0002362936,0.0004827995,0.0004503024,0.000008127765,0.00002311425,0.000002179466,0.0002635759],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003413906,"threshold_uncertainty_score":0.01142067,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07189860545296999,"score_gpt":0.3901590398362424,"score_spread":0.3182604343832725,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}