{"id":"W4396962257","doi":"10.1161/atvbaha.124.320790","title":"De Novo Elastin Assembly Alleviates Development of Supravalvular Aortic Stenosis—Brief Report","year":2024,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Aortic aneurysm repair treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Center for Advancing Translational Sciences; National Heart, Lung, and Blood Institute; National Institutes of Health; National Institute of General Medical Sciences; U.S. Department of Defense","keywords":"Elastin; Supravalvular aortic stenosis; Induced pluripotent stem cell; Vascular smooth muscle; Tropoelastin; Medicine; Cell biology; Internal medicine; Biology; Smooth muscle; Pathology; Stenosis; Embryonic stem cell; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001853567,0.0004515026,0.0003442744,0.0003400889,0.0001482245,0.000250929,0.0002642295,0.0005112002,0.00172042],"category_scores_gemma":[0.00009750365,0.00009747139,0.0002496623,0.0001496545,0.0002543581,0.0002077753,0.0002167432,0.000844312,0.0002822323],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001226693,"about_ca_system_score_gemma":0.0002111764,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001188171,"about_ca_topic_score_gemma":0.0002426591,"domain_scores_codex":[0.9998837,0.00002057583,0.00001874017,0.00002252824,0.00002697327,0.00002763565],"domain_scores_gemma":[0.9998858,0.00001605014,0.00003905289,0.00001040539,0.00001377857,0.00003480622],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001492002,0.0005647401,0.0004234911,0.0008180179,0.00005045989,0.0007592041,0.00005468449,0.00007458299,0.9665363,0.0005191691,0.0007005982,0.02800671],"study_design_scores_gemma":[0.0002224376,0.005755128,0.007016693,0.00007615909,0.0002337156,0.003057953,0.000103487,0.0003843282,0.9515558,0.0002594003,0.03131759,0.00001727094],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9326383,0.04889884,0.009131731,0.001727845,0.0009985948,0.0001979338,0.0006745509,0.0004082802,0.00532381],"genre_scores_gemma":[0.9553843,0.02728616,0.004243405,0.0007723994,0.0006757085,0.0001601373,0.0009637487,0.00004469445,0.01046954],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00172042,"threshold_uncertainty_score":0.005755424,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03589071258478683,"score_gpt":0.3103631333632005,"score_spread":0.2744724207784137,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}