{"id":"W4396972100","doi":"10.1002/ajh.27366","title":"Combination therapy with hypomethylating agents and venetoclax versus intensive induction chemotherapy in <i>IDH1</i>‐ or <i>IDH2</i>‐mutant newly diagnosed acute myeloid leukemia—A multicenter cohort study","year":2024,"lang":"en","type":"article","venue":"American Journal of Hematology","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Institutes of Health; Daiichi-Sankyo; bluebird bio; Sarepta Therapeutics; Sierra Oncology; Jazz Pharmaceuticals; Dana-Farber Cancer Institute; Celgene","keywords":"Venetoclax; IDH1; Medicine; IDH2; Myeloid leukemia; Hypomethylating agent; Oncology; Internal medicine; Chemotherapy; Mutant; Leukemia; Biology; Gene; Genetics; DNA methylation","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001833074,0.0009023168,0.001892976,0.0004141163,0.0005838263,0.001184784,0.0008504798,0.0008702077,0.002041084],"category_scores_gemma":[0.001729662,0.0005040615,0.002120385,0.0007403119,0.000531261,0.0009491709,0.0004851644,0.00176442,0.0004139182],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009444144,"about_ca_system_score_gemma":0.00114234,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001625609,"about_ca_topic_score_gemma":0.001969233,"domain_scores_codex":[0.9990933,0.0003522265,0.00006661313,0.000216427,0.0001091052,0.0001623477],"domain_scores_gemma":[0.9984773,0.0002176661,0.000460593,0.0001849282,0.0001048259,0.0005546288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.5771872,0.03731095,0.3096684,0.000451442,0.008630302,0.0007023743,0.0005737535,0.0009489874,0.009073866,0.0001860695,0.002156334,0.05311038],"study_design_scores_gemma":[0.07942779,0.4574512,0.439877,0.0002134001,0.008958019,0.001409651,0.0007979447,0.002657805,0.002084883,0.0003501786,0.006607851,0.000164326],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997593,0.001437098,0.000103785,0.00006587004,0.00004754234,0.0002197895,0.0002835954,0.000005359869,0.0002440212],"genre_scores_gemma":[0.996357,0.001273049,0.0003116778,0.0002540029,0.0002025173,0.0002709864,0.0008313651,0.000007648951,0.0004915916],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002041084,"threshold_uncertainty_score":0.009694278,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0230669026269304,"score_gpt":0.3297877690618693,"score_spread":0.3067208664349389,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}