{"id":"W4396978115","doi":"10.1021/acsinfecdis.4c00009","title":"Identification and Validation of Compounds Targeting <i>Leishmania major</i> Leucyl-Aminopeptidase M17","year":2024,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Ministerstvo Školství, Mládeže a Tělovýchovy; Wellcome Trust; University of Dundee","keywords":"Identification (biology); Leishmania; Biology; Computational biology; Aminopeptidase; Virology; Parasite hosting; Microbiology; Genetics; Ecology; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003278902,0.0005382631,0.0005038413,0.0003435775,0.0001453918,0.0003324293,0.0003654136,0.0003545761,0.001456295],"category_scores_gemma":[0.0002366831,0.000174029,0.0004386316,0.0003316948,0.0001877657,0.000176634,0.0002224957,0.0004367004,0.000588558],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002944581,"about_ca_system_score_gemma":0.0004753121,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007371029,"about_ca_topic_score_gemma":0.0008864056,"domain_scores_codex":[0.9998552,0.00002690083,0.00001415261,0.00002444988,0.00004918538,0.00003007106],"domain_scores_gemma":[0.9998688,0.0000145621,0.00003441982,0.00001227262,0.00004458735,0.00002542663],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001826976,0.0001096188,0.0002016024,0.00009023218,0.00001684048,0.0000437893,0.00000943217,0.000239124,0.9962365,0.0000541824,0.00009238192,0.002723639],"study_design_scores_gemma":[0.0000978186,0.002192752,0.001407655,0.00001034664,0.00004174772,0.0002387669,0.00001601628,0.000600442,0.9916375,0.00001802179,0.003732459,0.000006419908],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9830337,0.004218556,0.006151655,0.0002115488,0.00004080648,0.000445399,0.001908378,0.000176291,0.003813768],"genre_scores_gemma":[0.9716069,0.004410365,0.01340975,0.0002617403,0.00001911467,0.0002557079,0.005149801,0.00006612816,0.004820635],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001456295,"threshold_uncertainty_score":0.004871786,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008895770413526466,"score_gpt":0.2647909153717923,"score_spread":0.2558951449582659,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}