{"id":"W4396978251","doi":"10.1182/blood.2023023659","title":"Mutational profile in previously treated patients with chronic lymphocytic leukemia progression on acalabrutinib or ibrutinib","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"AstraZeneca (Canada)","funders":"National Cancer Institute","keywords":"Ibrutinib; Chronic lymphocytic leukemia; Medicine; Leukemia; Internal medicine; Cancer research; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002722069,0.0003411511,0.0004170449,0.0003668708,0.00007584047,0.00008101539,0.0001743161,0.000212659,0.0006595105],"category_scores_gemma":[0.0002384087,0.0002104213,0.00008393903,0.001033821,0.0001577576,0.0001458502,0.00007864932,0.0004112581,0.0005122732],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.04494559,"about_ca_system_score_gemma":0.04642726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002054051,"about_ca_topic_score_gemma":0.00007316004,"domain_scores_codex":[0.9968376,0.00009212816,0.0004648937,0.000756496,0.001094385,0.0007545147],"domain_scores_gemma":[0.9987602,0.000314846,0.00007121162,0.0004532185,0.0001403208,0.0002602599],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.08987828,0.02580091,0.1942987,0.0414085,0.006452781,0.08341615,0.01032876,0.00408374,0.004519776,0.002796027,0.02758924,0.5094271],"study_design_scores_gemma":[0.5533857,0.02753421,0.1526235,0.03293721,0.001498244,0.00296064,0.000142275,0.1631824,0.05327993,0.0001027715,0.01021255,0.002140579],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931377,0.0008069237,0.000004899653,0.00006987245,0.00008707999,0.002608298,0.00003294706,0.0003081954,0.002944043],"genre_scores_gemma":[0.995293,0.00004864027,0.0003611579,0.000076999,0.0002342639,0.0005047851,0.0004186366,0.00009787605,0.002964635],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5072865,"threshold_uncertainty_score":0.9589786,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01401930413558739,"score_gpt":0.3052712973451345,"score_spread":0.2912519932095471,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}