{"id":"W4396978251","doi":"10.1182/blood.2023023659","title":"Mutational profile in previously treated patients with chronic lymphocytic leukemia progression on acalabrutinib or ibrutinib","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"AstraZeneca (Canada)","funders":"National Cancer Institute","keywords":"Ibrutinib; Chronic lymphocytic leukemia; Medicine; Leukemia; Internal medicine; Cancer research; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001790222,0.0001899285,0.0002888074,0.0006243658,0.0003171445,0.0004509688,0.0001592353,0.0003214329,0.001579553],"category_scores_gemma":[0.0006568753,0.0001001491,0.0001816216,0.000530681,0.0001451789,0.0002210702,0.0001363379,0.0002685573,0.0002689578],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002881847,"about_ca_system_score_gemma":0.0001667392,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00132368,"about_ca_topic_score_gemma":0.001700688,"domain_scores_codex":[0.9997968,0.00003091783,0.00002552704,0.00005476782,0.00004378995,0.00004829429],"domain_scores_gemma":[0.9996518,0.00007612792,0.0001054344,0.00001926852,0.00003657115,0.0001107244],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009727746,0.0001522846,0.9809912,0.00002010327,0.0000616317,0.001457791,0.000187664,0.000104085,0.008031295,0.00002731304,0.0001947327,0.007799104],"study_design_scores_gemma":[0.00006055842,0.0007723806,0.9928121,0.000008054351,0.0000453482,0.004435891,0.0001069696,0.000221516,0.0007761782,0.00001835481,0.0007368252,0.000005825171],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990368,0.0002300456,0.00002311887,0.00001567287,0.000002483011,0.000005547327,0.0001335524,0.00000355552,0.0005491606],"genre_scores_gemma":[0.9993606,0.00008126075,0.00003506559,0.00003136322,0.000007677616,0.000007311829,0.0003168035,0.000001913148,0.0001579612],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001579553,"threshold_uncertainty_score":0.005284131,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01401930413558739,"score_gpt":0.3052712973451345,"score_spread":0.2912519932095471,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}