{"id":"W4396978743","doi":"10.7554/elife.95694","title":"Comment on 'Accumbens cholinergic interneurons dynamically promote dopamine release and enable motivation'","year":2024,"lang":"en","type":"letter","venue":"eLife","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Mental Health; Irma T. Hirschl Trust; York University; Howard Hughes Medical Institute; National Institutes of Health; National Science Foundation","keywords":"Optogenetics; Dopamine; Neuroscience; Cholinergic; Acetylcholine; Nucleus accumbens; Striatum; Nicotinic agonist; Cholinergic neuron; Chemistry; Stimulation; Neurotransmitter; Biology; Endocrinology; Receptor; Central nervous system; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00345834,0.001134063,0.001100227,0.0005367888,0.00189992,0.002152405,0.002425713,0.03080646,0.004964944],"category_scores_gemma":[0.01451891,0.0005569315,0.001274123,0.0003636926,0.003241408,0.002107145,0.0009523582,0.02841703,0.007688219],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003288946,"about_ca_system_score_gemma":0.001827006,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002462241,"about_ca_topic_score_gemma":0.002685318,"domain_scores_codex":[0.9979948,0.0003869199,0.0002665942,0.0004024986,0.0007149736,0.0002341525],"domain_scores_gemma":[0.9947621,0.003415782,0.000297995,0.0002096285,0.0008444976,0.000469979],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001500197,0.00005165796,0.000291925,0.00009194836,0.00001594608,0.001777174,0.00007782887,0.00007220938,0.0004996074,0.002346048,0.9858584,0.008767258],"study_design_scores_gemma":[0.000194667,0.0002558403,0.002108073,0.0002494416,0.00005784619,0.002261808,0.000277743,0.0006892652,0.00158965,0.01164807,0.9805759,0.0000918095],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0006966087,0.00183388,0.000364592,0.914817,0.07966083,0.00002210561,0.0001295711,0.0001816877,0.002293751],"genre_scores_gemma":[0.005962794,0.001938379,0.0003003202,0.8818387,0.1013226,0.00005265206,0.00004241304,0.00004609551,0.008496084],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.03080646,"threshold_uncertainty_score":0.02386302,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01254377136284433,"score_gpt":0.2382369529087936,"score_spread":0.2256931815459493,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}