{"id":"W4396978955","doi":"10.1016/j.jtocrr.2024.100682","title":"Reproducibility of Assessment of Lepidic (Noninvasive) Patterns in Lung Adenocarcinoma With Cytokeratin Immunostain Compared With Hematoxylin and Eosin and the Proposed New International Association for the Study of Lung Cancer (IASLC) Algorithm","year":2024,"lang":"en","type":"article","venue":"JTO Clinical and Research Reports","topic":"Lung Cancer Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto","funders":"Canadian Institutes of Health Research; Princess Margaret Cancer Foundation","keywords":"Medicine; Lung cancer; Cytokeratin; Adenocarcinoma; H&E stain; Pathology; Lung; Reproducibility; Stain; Oncology; Radiology; Cancer; Internal medicine; Immunohistochemistry; Staining","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.009548192,0.0001038335,0.0005264503,0.00007161879,0.00006584299,0.00003875459,0.00005358857,0.00005066535,0.000009285203],"category_scores_gemma":[0.0008583301,0.00004502791,0.00005224267,0.0001729398,0.0003006665,0.00005098756,0.00009831171,0.000307715,8.058144e-9],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001874463,"about_ca_system_score_gemma":0.0008653131,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006227848,"about_ca_topic_score_gemma":0.001472847,"domain_scores_codex":[0.9972113,0.0003537427,0.0008506106,0.0006276766,0.0008052678,0.0001513652],"domain_scores_gemma":[0.9961274,0.002450743,0.0003182233,0.0004799448,0.0005580559,0.00006558366],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009265175,0.0008239932,0.9898673,0.0006503979,0.001007105,0.0001090203,0.001670851,0.00001187801,0.00001502697,0.00003541439,0.0002641725,0.004618339],"study_design_scores_gemma":[0.005757954,0.001489906,0.9826201,0.001120784,0.0003237505,0.00003472987,0.001367286,0.006783319,0.0003479412,0.00007071513,0.00003391326,0.0000496673],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848264,0.005351679,0.00009948963,0.006191516,0.00007830784,0.003397537,0.00002207402,0.000004784949,0.00002815484],"genre_scores_gemma":[0.9975737,0.001625304,0.0002328658,0.00001547616,0.00008318578,0.0002668435,0.000008922828,0.00001027343,0.0001834302],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01274724,"threshold_uncertainty_score":0.9414685,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06632887354129716,"score_gpt":0.4680261844391818,"score_spread":0.4016973108978846,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}