{"id":"W4396979010","doi":"10.1016/j.jtocrr.2024.100691","title":"EGFR-Mutated Lung Adenocarcinoma With Li–Fraumeni Syndrome: The Imperative for Germline Testing in Patients With a Family History, a Case Report","year":2024,"lang":"en","type":"article","venue":"JTO Clinical and Research Reports","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Shionogi; Astellas Pharma; Kyowa Hakko Kirin; Eisai; Chugai Pharmaceutical; Celltrion; Kissei; Taiho Pharmaceutical; Genomic Health; Daiichi-Sankyo; Amgen; Pfizer; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Li–Fraumeni syndrome; Germline; Family history; Genetic testing; Medicine; Germline mutation; Oncology; Lung cancer; Adenocarcinoma; Internal medicine; Cancer research; Mutation; Genetics; Cancer; Biology; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003291624,0.001096668,0.0006028265,0.00174139,0.001767459,0.00128304,0.0005443139,0.002732837,0.001496733],"category_scores_gemma":[0.002192046,0.0007070394,0.0006705438,0.0007863509,0.001151231,0.001269537,0.000859199,0.002019948,0.000437892],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008294003,"about_ca_system_score_gemma":0.0007284956,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003666975,"about_ca_topic_score_gemma":0.004990704,"domain_scores_codex":[0.9996295,0.0000604396,0.00004909227,0.00008657905,0.00007037954,0.0001039269],"domain_scores_gemma":[0.99911,0.000329427,0.0002316425,0.00005598018,0.00004884966,0.0002240472],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.00001349198,0.0000183474,0.01203223,0.00001995934,0.000005796188,0.9850472,0.0001334174,0.00006175647,0.000593721,0.0001236693,0.0003637029,0.001586671],"study_design_scores_gemma":[0.000002067524,0.00001452673,0.002528131,0.000009906596,0.000008236536,0.9965922,0.00007541628,0.0001162956,0.0002063425,0.00008315727,0.0003589163,0.000004864211],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9694468,0.008170991,0.003750806,0.006529428,0.0002881641,0.00013095,0.0002115516,0.0001897377,0.01128167],"genre_scores_gemma":[0.9943598,0.002053942,0.00150486,0.0006667165,0.000576594,0.000015793,0.00005507014,0.00002027131,0.0007469962],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003666975,"threshold_uncertainty_score":0.007291257,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08971594190306834,"score_gpt":0.4467703342793563,"score_spread":0.3570543923762879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}