{"id":"W4396979010","doi":"10.1016/j.jtocrr.2024.100691","title":"EGFR-Mutated Lung Adenocarcinoma With Li–Fraumeni Syndrome: The Imperative for Germline Testing in Patients With a Family History, a Case Report","year":2024,"lang":"en","type":"article","venue":"JTO Clinical and Research Reports","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Shionogi; Astellas Pharma; Kyowa Hakko Kirin; Eisai; Chugai Pharmaceutical; Celltrion; Kissei; Taiho Pharmaceutical; Genomic Health; Daiichi-Sankyo; Amgen; Pfizer; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Li–Fraumeni syndrome; Germline; Family history; Genetic testing; Medicine; Germline mutation; Oncology; Lung cancer; Adenocarcinoma; Internal medicine; Cancer research; Mutation; Genetics; Cancer; Biology; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00229922,0.0001746415,0.0003960018,0.0001691388,0.0002116054,0.00006655481,0.00003913278,0.0001021517,0.00001840587],"category_scores_gemma":[0.001452759,0.00007591354,0.00007099567,0.0004700912,0.0004579265,0.0001153012,0.00005679277,0.0006377473,0.000001339791],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004487188,"about_ca_system_score_gemma":0.001800506,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009772067,"about_ca_topic_score_gemma":0.0001818238,"domain_scores_codex":[0.9973093,0.0001343604,0.000784591,0.0007024743,0.0006726641,0.0003965806],"domain_scores_gemma":[0.9971493,0.001145818,0.0001334229,0.000399739,0.0009130102,0.0002587386],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005452422,0.0004145209,0.5629981,0.0002170995,0.0003641135,0.4277586,0.0005764308,0.000004331576,0.00000530959,0.00001148465,0.003100753,0.004004034],"study_design_scores_gemma":[0.003613725,0.005703069,0.8814827,0.001034599,0.0004329988,0.09824274,0.0005086091,0.001431355,0.000004506733,0.0001073042,0.007238355,0.0002000525],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992786,0.002122993,0.00004610175,0.001654302,0.0001753338,0.002484832,0.00001384852,0.00005390244,0.0006626126],"genre_scores_gemma":[0.9948347,0.00002364605,0.0007685134,0.0001129634,0.0001114113,0.00051248,0.00006732303,0.00003910602,0.003529861],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3295159,"threshold_uncertainty_score":0.319402,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08971594190306834,"score_gpt":0.4467703342793563,"score_spread":0.3570543923762879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}