{"id":"W4396980194","doi":"10.1093/ageing/afae091","title":"The brain insulin receptor gene network and associations with frailty index","year":2024,"lang":"en","type":"article","venue":"Age and Ageing","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Queensway-Carleton Hospital; McGill University; Douglas Mental Health University Institute","funders":"Canadian Institutes of Health Research; Signe ja Ane Gyllenbergin Säätiö; Sydäntutkimussäätiö; Samfundet Folkhälsan; Finska Läkaresällskapet; Juho Vainion Säätiö; Novo Nordisk Fonden; Academy of Finland","keywords":"Medicine; Frailty Index; Index (typography); Insulin receptor; Receptor; Insulin; Gene; Internal medicine; Gerontology; Genetics; Insulin resistance; World Wide Web; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003327724,0.00007652234,0.00008240978,0.0000101622,0.0002927363,0.00007225153,0.00004549708,0.00009450722,0.000003106732],"category_scores_gemma":[0.0001293274,0.00005087951,0.0000216782,0.00007211097,0.0000573941,0.000002709102,0.0000601738,0.00008937561,0.000002235239],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006466382,"about_ca_system_score_gemma":0.00002620519,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004130649,"about_ca_topic_score_gemma":0.0002529013,"domain_scores_codex":[0.9994071,0.00007180328,0.0001106282,0.000188996,0.0000418679,0.0001796362],"domain_scores_gemma":[0.9996804,0.0001304401,0.00003522886,0.00009716264,0.00001851106,0.00003823997],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.00009467913,0.00006556446,0.1955966,0.00007287223,0.00157018,0.0006548701,0.00161756,0.001633053,0.09500203,0.004952205,0.2000788,0.4986616],"study_design_scores_gemma":[0.000294422,0.0001664819,0.5868719,0.00002973125,0.00003331731,0.00001700613,0.000139104,0.0009380924,0.0002310475,0.001839697,0.4092282,0.0002109912],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9854085,0.008332128,0.003105812,0.002362292,0.0001033217,0.00008592156,0.00001217648,0.00001426643,0.0005755508],"genre_scores_gemma":[0.9954693,0.001419415,0.0008570397,0.0005859989,0.0003653421,0.00001335375,0.00007040051,0.00001083449,0.00120829],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4984506,"threshold_uncertainty_score":0.2251521,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01152581857919758,"score_gpt":0.2521255099344135,"score_spread":0.2405996913552159,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}