{"id":"W4396989803","doi":"10.1681/asn.20223311s1187d","title":"A Phase 2a Study to Evaluate the Safety and Efficacy of Tegoprubart (AT-1501) in Patients With IgA Nephropathy (IgAN)","year":2022,"lang":"en","type":"article","venue":"Journal of the American Society of Nephrology","topic":"Renal Diseases and Glomerulopathies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Nephropathy; Medicine; Glomerulonephritis; Internal medicine; Urology; Gastroenterology; Kidney; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002266969,0.001729058,0.00208539,0.0003795928,0.0005262581,0.000819761,0.0008899952,0.001720825,0.004890244],"category_scores_gemma":[0.0009496042,0.0006279019,0.00147807,0.0002866184,0.0009182098,0.0008680778,0.0003818301,0.003495751,0.001346804],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009628063,"about_ca_system_score_gemma":0.002147706,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007905742,"about_ca_topic_score_gemma":0.001871081,"domain_scores_codex":[0.9993778,0.0002916002,0.00002899739,0.00009657309,0.000080649,0.0001243973],"domain_scores_gemma":[0.9986625,0.0001752227,0.0002470582,0.00010852,0.0001071371,0.000699638],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7218546,0.164625,0.008505139,0.0006695845,0.001122116,0.0003203479,0.0002220472,0.001208654,0.04754998,0.0002107295,0.003781392,0.04993033],"study_design_scores_gemma":[0.3652632,0.6209667,0.009166052,0.00002074557,0.0002212855,0.0002059117,0.00002992603,0.0004672061,0.002031157,0.0001228799,0.00148595,0.00001896921],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901023,0.0009519817,0.0006469818,0.000497913,0.0001104996,0.004773458,0.001512107,0.00009596215,0.001308833],"genre_scores_gemma":[0.9768943,0.001174609,0.003845493,0.00233181,0.000280801,0.007955967,0.003638365,0.0000408866,0.003837737],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004890244,"threshold_uncertainty_score":0.01635945,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01043625739737153,"score_gpt":0.289243518754667,"score_spread":0.2788072613572954,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}