{"id":"W4396991754","doi":"10.1681/asn.20213210s1b7c","title":"A Randomized, Double-Blind, Phase 2 Study to Evaluate the Tolerability, Feasibility, and Efficacy of AKST1210 in Patients on Hemodialysis with ESRD and Cognitive Impairment","year":2021,"lang":"en","type":"article","venue":"Journal of the American Society of Nephrology","topic":"Blood Pressure and Hypertension Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Tolerability; Hemodialysis; Medicine; Cognitive impairment; Randomized controlled trial; Double blind; Intensive care medicine; Internal medicine; Disease; Adverse effect; Alternative medicine; Pathology; Placebo","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002494196,0.001626883,0.003311784,0.000426618,0.0007256143,0.0009653111,0.0009428095,0.002024108,0.007871551],"category_scores_gemma":[0.002229879,0.0007972061,0.00108312,0.0004430277,0.001464634,0.001301456,0.0004984753,0.002425364,0.001110229],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006471367,"about_ca_system_score_gemma":0.002586231,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005910703,"about_ca_topic_score_gemma":0.001165418,"domain_scores_codex":[0.9991328,0.0004184795,0.00006234965,0.000184753,0.00007351855,0.0001282007],"domain_scores_gemma":[0.9981693,0.0004438596,0.0003409717,0.0001784503,0.0001965183,0.0006708129],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9604455,0.02731286,0.0008435544,0.0002472255,0.0002889739,0.00004093771,0.00005205974,0.0001440447,0.002499305,0.00005318082,0.0004593496,0.007613075],"study_design_scores_gemma":[0.8293855,0.1681477,0.001407936,0.00001128945,0.000109154,0.00002694952,0.00001513107,0.0001792809,0.0002179266,0.0000651067,0.000425405,0.000008567461],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.978761,0.00154669,0.001039666,0.0004698191,0.0004246423,0.01527904,0.0009600954,0.0001083976,0.001410766],"genre_scores_gemma":[0.9656413,0.001192894,0.003618607,0.001708993,0.0006419231,0.02313209,0.0009053257,0.0000220434,0.003136787],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007871551,"threshold_uncertainty_score":0.02633291,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04972707680878759,"score_gpt":0.3561160881542927,"score_spread":0.3063890113455051,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}