{"id":"W4396992736","doi":"10.1681/asn.20213210s1745a","title":"Apabetalone Downregulates Fibrotic, Inflammatory and Calcific Processes in Renal Mesangial Cells: Mechanism for Reduced Cardiac Events in CKD Patients","year":2021,"lang":"en","type":"article","venue":"Journal of the American Society of Nephrology","topic":"Potassium and Related Disorders","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Resverlogix (Canada)","funders":"","keywords":"Mechanism (biology); Medicine; Inflammation; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002569864,0.0001235282,0.0006104377,0.00007029894,0.00003731002,0.000002805755,0.0001036147,0.0001158782,0.000004084475],"category_scores_gemma":[0.0001163423,0.00008730152,0.0002922257,0.0003416946,0.0002991288,0.00005630233,0.0000579164,0.0002956623,2.503881e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006588777,"about_ca_system_score_gemma":0.0003663394,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003348929,"about_ca_topic_score_gemma":0.00001029584,"domain_scores_codex":[0.9987917,0.0001284443,0.0004999774,0.0001429622,0.000205056,0.0002318559],"domain_scores_gemma":[0.9987764,0.0001481966,0.0006000262,0.0001266937,0.0002790884,0.0000695853],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001346145,0.0006071305,0.05323264,0.0004468832,0.0007614715,0.00001236222,0.003300579,0.0001457375,0.9339334,0.00002090447,0.004505133,0.001687629],"study_design_scores_gemma":[0.01040303,0.001798189,0.8902853,0.0005579074,0.000540591,0.0001121948,0.004281319,0.0001977955,0.08814455,0.001956347,0.001448186,0.0002746199],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960393,0.0007215799,0.00001735177,0.002826015,0.000128024,0.0002425604,0.000008526594,0.000003065871,0.00001353161],"genre_scores_gemma":[0.9967196,0.001023317,0.001159098,0.0009604791,0.00007048741,0.000006309347,0.000003991874,0.000014936,0.00004177462],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8457888,"threshold_uncertainty_score":0.3560053,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007264338360363721,"score_gpt":0.2409210520103263,"score_spread":0.2336567136499626,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}