{"id":"W4396998188","doi":"10.1681/asn.20203110s1221b","title":"Switching from Agalsidase Alfa to Pegunigalsidase Alfa for Treating Fabry Disease: One Year of Treatment Data from Bridge, a Phase 3 Open-Label Study","year":2020,"lang":"en","type":"article","venue":"Journal of the American Society of Nephrology","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"","keywords":"Fabry disease; Medicine; Open label; Bridge (graph theory); Internal medicine; Disease; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003890195,0.001271908,0.003682154,0.0004066298,0.0006690613,0.00148586,0.0009518788,0.002348098,0.004115898],"category_scores_gemma":[0.001972413,0.0005179486,0.002493624,0.0004399555,0.0007998709,0.001333258,0.0004968023,0.004129522,0.001201198],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007575516,"about_ca_system_score_gemma":0.001116234,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007561647,"about_ca_topic_score_gemma":0.001025336,"domain_scores_codex":[0.9988981,0.0004259273,0.00007903455,0.0001619339,0.0001757151,0.0002591401],"domain_scores_gemma":[0.99809,0.0004083978,0.0004298644,0.0002287857,0.0001758377,0.000667083],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7199615,0.0771426,0.01263934,0.001150438,0.003319471,0.0005947651,0.0005980247,0.00203353,0.04406363,0.0001735281,0.0105155,0.1278077],"study_design_scores_gemma":[0.3860051,0.5577375,0.0425394,0.0001210259,0.001386034,0.000526917,0.0001141005,0.001435176,0.004723503,0.0002625223,0.005079683,0.00006907936],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881091,0.003990595,0.0008699327,0.0004533746,0.0001465749,0.001541924,0.00254731,0.0001419483,0.002199317],"genre_scores_gemma":[0.9801562,0.002267225,0.001086603,0.002742329,0.0002760891,0.002749849,0.008127182,0.00006311878,0.002531309],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004115898,"threshold_uncertainty_score":0.02057362,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1609814699204419,"score_gpt":0.4218736717155283,"score_spread":0.2608922017950864,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}