{"id":"W4396999533","doi":"10.1681/asn.20203110s1502a","title":"STAGED-PKD: An Enriched, Seamless, Two-Stage Study for Venglustat Assessment in ADPKD","year":2020,"lang":"en","type":"article","venue":"Journal of the American Society of Nephrology","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Stage (stratigraphy); Medicine; Internal medicine; Urology; Oncology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003641425,0.001563734,0.002124535,0.0003868382,0.0005015946,0.0009242411,0.0006939972,0.001186421,0.003754078],"category_scores_gemma":[0.001615656,0.0005706754,0.001438226,0.0003886916,0.0007596781,0.0009923413,0.0007031146,0.001372627,0.0006638229],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005664625,"about_ca_system_score_gemma":0.001719254,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005399135,"about_ca_topic_score_gemma":0.001216444,"domain_scores_codex":[0.9985838,0.0008305954,0.00009255562,0.0001996269,0.0001356732,0.0001576469],"domain_scores_gemma":[0.9989424,0.0001740987,0.0001977717,0.0001518045,0.0001039472,0.0004298961],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9403239,0.02297534,0.006665599,0.0004005107,0.0007762615,0.00007540941,0.0001204916,0.0005904883,0.006643327,0.0001972591,0.0009076792,0.02032374],"study_design_scores_gemma":[0.6757411,0.3018086,0.01806184,0.00003807073,0.0005734751,0.0001029243,0.00004377173,0.0006853891,0.0009442471,0.0002770855,0.001679969,0.00004345305],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871269,0.001241227,0.001314528,0.0002345854,0.00011839,0.007344759,0.00110116,0.00006536709,0.001452924],"genre_scores_gemma":[0.9811793,0.0005799199,0.004303774,0.0007504706,0.0001736912,0.009920196,0.00176401,0.00002028283,0.001308377],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003754078,"threshold_uncertainty_score":0.01925796,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02259690285395525,"score_gpt":0.3304619884328486,"score_spread":0.3078650855788934,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}