{"id":"W4397002107","doi":"10.1021/acs.orglett.4c01547","title":"A Dual Ni/Photoredox Cross-Coupling Approach toward Mandelic Acids","year":2024,"lang":"en","type":"article","venue":"Organic Letters","topic":"Catalytic C–H Functionalization Methods","field":"Chemistry","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Ontario Ministry of Research and Innovation; Natural Sciences and Engineering Research Council of Canada; University of Toronto; Ontario Ministry of Research, Innovation and Science; Canada Research Chairs; Canada Foundation for Innovation; Ontario Research Foundation; Alfred P. Sloan Foundation","keywords":"Chemistry; Mandelic acid; Dual (grammatical number); Coupling (piping); Combinatorial chemistry; Photochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003233406,0.0002473912,0.0002065794,0.00009860624,0.0001109833,0.0003547179,0.0002259009,0.0001558781,0.006357191],"category_scores_gemma":[0.0001362659,0.0002480738,0.0001342763,0.0004177525,0.0001135299,0.0001997719,0.0001249467,0.0003575023,0.0003898601],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003292974,"about_ca_system_score_gemma":0.0001223283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002620612,"about_ca_topic_score_gemma":8.272384e-7,"domain_scores_codex":[0.9982693,0.000009616725,0.0003430887,0.00060099,0.0004267941,0.000350216],"domain_scores_gemma":[0.9992408,0.0001159473,0.00005268927,0.0004366674,0.00004587099,0.0001080884],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001710183,0.0000313331,0.001480313,0.0004223943,0.000123371,0.00005828117,0.000554068,0.0003099344,0.9839099,0.0002993431,0.01253367,0.000260269],"study_design_scores_gemma":[0.001729992,0.00002109207,0.001140873,0.0001930734,0.0002947673,0.0008871377,0.0005176371,0.04583928,0.8666832,0.0003197473,0.08093851,0.001434678],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9082109,0.0003974407,0.08414355,0.001922242,0.001183492,0.0001017736,0.00003816324,0.0007704525,0.003232029],"genre_scores_gemma":[0.987498,0.00001623972,0.00372444,0.001736222,0.001633014,0.00004419521,0.0003060312,0.0001465353,0.004895255],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1172267,"threshold_uncertainty_score":0.9999971,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02483388763071498,"score_gpt":0.2850435970213023,"score_spread":0.2602097093905874,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}