{"id":"W4397002346","doi":"10.1111/dom.15650","title":"Inclisiran in individuals with diabetes or obesity: Post hoc pooled analyses of the <scp>ORION</scp> ‐9, <scp>ORION</scp> ‐10 and <scp>ORION</scp> ‐11 Phase 3 randomized trials","year":2024,"lang":"en","type":"article","venue":"Diabetes Obesity and Metabolism","topic":"Pharmacology and Obesity Treatment","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"NIHR Imperial Biomedical Research Centre; Imperial College London; Novartis Pharma; National Institute for Health and Care Research","keywords":"Medicine; Placebo; Prediabetes; Body mass index; Internal medicine; Post-hoc analysis; Type 2 diabetes; Obesity; Diabetes mellitus; Randomized controlled trial; Cholesterol; Adverse effect; Endocrinology; Gastroenterology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.007056225,0.001304442,0.005570624,0.001385516,0.0006631302,0.0003253779,0.0006047298,0.0008185599,0.00008973611],"category_scores_gemma":[0.01135987,0.0007926702,0.001016763,0.002069768,0.001247318,0.0007831865,0.000548263,0.001159535,0.00003862906],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001173979,"about_ca_system_score_gemma":0.0006355153,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001611883,"about_ca_topic_score_gemma":0.0001622179,"domain_scores_codex":[0.990589,0.00311031,0.002064789,0.001519459,0.001179536,0.001536948],"domain_scores_gemma":[0.9800467,0.01670562,0.001029514,0.0009371291,0.0004809508,0.000800074],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002868609,0.01300138,0.8090659,0.004610996,0.02640655,0.0006529578,0.02283689,0.00006758836,0.09176587,0.00285526,0.01348841,0.01237964],"study_design_scores_gemma":[0.2393813,0.00168591,0.4407684,0.002069703,0.03247664,0.0000544154,0.002138125,0.0006225788,0.22801,0.002676535,0.04973235,0.0003840713],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9305292,0.06299852,0.00002175912,0.0004358127,0.0009501525,0.003691802,0.0007517207,0.0002389841,0.0003820794],"genre_scores_gemma":[0.9877877,0.00589584,0.0005580911,0.00156425,0.0007074151,0.0004380091,0.0003592632,0.0001246966,0.002564725],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3682975,"threshold_uncertainty_score":0.9999707,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03341380485866252,"score_gpt":0.3304703654264591,"score_spread":0.2970565605677966,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}