{"id":"W4397002346","doi":"10.1111/dom.15650","title":"Inclisiran in individuals with diabetes or obesity: Post hoc pooled analyses of the <scp>ORION</scp> ‐9, <scp>ORION</scp> ‐10 and <scp>ORION</scp> ‐11 Phase 3 randomized trials","year":2024,"lang":"en","type":"article","venue":"Diabetes Obesity and Metabolism","topic":"Pharmacology and Obesity Treatment","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"NIHR Imperial Biomedical Research Centre; Imperial College London; Novartis Pharma; National Institute for Health and Care Research","keywords":"Medicine; Placebo; Prediabetes; Body mass index; Internal medicine; Post-hoc analysis; Type 2 diabetes; Obesity; Diabetes mellitus; Randomized controlled trial; Cholesterol; Adverse effect; Endocrinology; Gastroenterology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01091767,0.001998116,0.00687775,0.0008556911,0.0002779024,0.00171903,0.0005070889,0.0009502427,0.002755677],"category_scores_gemma":[0.008978341,0.0006024537,0.01671002,0.001129436,0.0003991924,0.000839268,0.0006531084,0.001188274,0.000229351],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004444971,"about_ca_system_score_gemma":0.0007863471,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009114675,"about_ca_topic_score_gemma":0.002367805,"domain_scores_codex":[0.9938711,0.004220553,0.0007990895,0.0006122865,0.0002865638,0.0002102831],"domain_scores_gemma":[0.9946012,0.002923079,0.001413687,0.000530151,0.0003711705,0.0001606919],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.4860423,0.0003723186,0.007763211,0.01111848,0.4722211,0.0001241053,0.00009079354,0.00128417,0.002958768,0.0001182945,0.0010191,0.01688743],"study_design_scores_gemma":[0.133337,0.02444027,0.04320752,0.0009001364,0.790391,0.0001737036,0.0001576486,0.002123093,0.001839093,0.000635308,0.002690175,0.0001050742],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8131498,0.1682966,0.006613166,0.0005456693,0.001102638,0.003202222,0.003737506,0.0003026241,0.003049847],"genre_scores_gemma":[0.9815906,0.01057635,0.002813828,0.0004480643,0.0002570057,0.001779863,0.001354121,0.00005541,0.001124716],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01091767,"threshold_uncertainty_score":0.0577389,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03341380485866252,"score_gpt":0.3304703654264591,"score_spread":0.2970565605677966,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}