{"id":"W4397005786","doi":"10.3390/cells13100859","title":"Lung Transplant Immunomodulation with Genetically Engineered Mesenchymal Stromal Cells—Therapeutic Window for Interleukin-10","year":2024,"lang":"en","type":"article","venue":"Cells","topic":"Transplantation: Methods and Outcomes","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; Toronto General Hospital; University of Toronto; Health Sciences Centre; University Health Network","funders":"Canadian Institutes of Health Research; Sigrid Juséliuksen Säätiö","keywords":"Medicine; Transplantation; Mesenchymal stem cell; Lung transplantation; Lung; CD8; Ex vivo; Inflammation; Cell therapy; Immunology; Immune system; Cancer research; Pathology; Cell; In vivo; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001673562,0.0002109608,0.0002843711,0.0001190691,0.0000460241,0.00005658149,0.00007827383,0.0001015499,0.0002453066],"category_scores_gemma":[0.000002323314,0.0001556904,0.0001523235,0.0001311814,0.0000445146,0.0000718825,0.000003748266,0.0001616336,0.00002861026],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004852087,"about_ca_system_score_gemma":0.0001049278,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006666457,"about_ca_topic_score_gemma":0.000004019209,"domain_scores_codex":[0.9988923,0.00003533081,0.0002754152,0.0003107938,0.0002003644,0.0002858089],"domain_scores_gemma":[0.9993848,0.0002362613,0.00002563281,0.0001910399,0.00005765402,0.0001046413],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00120884,0.00007927443,0.0007544002,0.001280141,0.0004504488,0.000147215,0.001473566,0.0005260611,0.9772443,0.0007028366,0.0001517432,0.01598125],"study_design_scores_gemma":[0.005503184,0.002048593,0.03498981,0.001008639,0.002124026,0.0002688588,0.0001550005,0.05243943,0.8875692,0.0001911866,0.01303375,0.0006682672],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5009838,0.001937588,0.4941683,0.0004116423,0.0007408526,0.0009505216,0.00012137,0.0001901555,0.0004957261],"genre_scores_gemma":[0.9550838,0.0000954963,0.04237659,0.0001101607,0.0002208434,0.0000421998,0.0001267296,0.00005380333,0.001890316],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4541,"threshold_uncertainty_score":0.6348872,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01406867533862567,"score_gpt":0.2824412298164941,"score_spread":0.2683725544778684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}