{"id":"W4397005786","doi":"10.3390/cells13100859","title":"Lung Transplant Immunomodulation with Genetically Engineered Mesenchymal Stromal Cells—Therapeutic Window for Interleukin-10","year":2024,"lang":"en","type":"article","venue":"Cells","topic":"Transplantation: Methods and Outcomes","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; Toronto General Hospital; University of Toronto; Health Sciences Centre; University Health Network","funders":"Canadian Institutes of Health Research; Sigrid Juséliuksen Säätiö","keywords":"Medicine; Transplantation; Mesenchymal stem cell; Lung transplantation; Lung; CD8; Ex vivo; Inflammation; Cell therapy; Immunology; Immune system; Cancer research; Pathology; Cell; In vivo; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002259181,0.0003362627,0.0002609822,0.0001742432,0.0000698055,0.000332474,0.0001479825,0.000256932,0.0009559632],"category_scores_gemma":[0.00006735219,0.00006299382,0.0002077478,0.00009089318,0.0002100118,0.0002278421,0.0001354105,0.0005391016,0.0001508748],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001115858,"about_ca_system_score_gemma":0.000155322,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008588665,"about_ca_topic_score_gemma":0.000186957,"domain_scores_codex":[0.9998877,0.00002899678,0.000008444177,0.00001855563,0.00002663219,0.0000297031],"domain_scores_gemma":[0.9999386,0.00001131618,0.00002194094,0.000007296276,0.000003454928,0.00001735032],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009148591,0.0005798719,0.0003952259,0.00008609797,0.00001088605,0.00007212185,0.00001756828,0.0001970306,0.9889793,0.000184517,0.00006183268,0.008500682],"study_design_scores_gemma":[0.000165066,0.0107468,0.004000113,0.00001878955,0.00006440472,0.0003938039,0.00003473612,0.001344052,0.9805912,0.00009410307,0.002541113,0.000005809807],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947484,0.001671266,0.00253644,0.00008579274,0.00005807242,0.00005045082,0.00006858819,0.00005291922,0.000727925],"genre_scores_gemma":[0.9963226,0.0009455468,0.001811705,0.00005972712,0.00003298728,0.00005427569,0.00009640769,0.000006291777,0.0006704575],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009559632,"threshold_uncertainty_score":0.003198028,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01406867533862567,"score_gpt":0.2824412298164941,"score_spread":0.2683725544778684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}