{"id":"W4397005841","doi":"10.3390/cells13100857","title":"Insights into PCSK9-LDLR Regulation and Trafficking via the Differential Functions of MHC-I Proteins HFE and HLA-C","year":2024,"lang":"en","type":"article","venue":"Cells","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"","keywords":"LDL receptor; Cell biology; Biology; Major histocompatibility complex; MHC class I; Extracellular; Human leukocyte antigen; Immune system; HLA-G; Chemistry; Biochemistry; Cholesterol; Genetics; Lipoprotein; Antigen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001353762,0.0001509229,0.0001494352,0.0001920465,0.0001247246,0.0003000062,0.0001155261,0.0001946089,0.0007120495],"category_scores_gemma":[0.00009478375,0.00006748295,0.0001295227,0.00009130948,0.000243954,0.0002087012,0.0001611011,0.0002926569,0.0001611298],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002790757,"about_ca_system_score_gemma":0.0001600314,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004901603,"about_ca_topic_score_gemma":0.0005150332,"domain_scores_codex":[0.9999048,0.00001761956,0.000008008185,0.00002568932,0.00001921106,0.00002480618],"domain_scores_gemma":[0.9999517,0.000008204736,0.00001366358,0.000004317931,0.000007323113,0.00001475227],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002286105,0.00001815314,0.001656782,0.00003060861,0.000006363812,0.0001732479,0.00003701722,0.00008672692,0.9945379,0.0004029799,0.00003088029,0.002790733],"study_design_scores_gemma":[0.00005046598,0.0002684112,0.1180461,0.00002156312,0.00004389267,0.001876827,0.0003850793,0.004481324,0.8681217,0.0007916244,0.005897624,0.0000153142],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994381,0.002754098,0.001530577,0.0001386729,0.00001088989,0.00000422529,0.00007237055,0.00001068878,0.001097579],"genre_scores_gemma":[0.9972495,0.00103382,0.0007257184,0.00004870176,0.000008680334,0.000003561359,0.00005740347,0.000002969022,0.0008696489],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007120495,"threshold_uncertainty_score":0.00238198,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009654143893492699,"score_gpt":0.2281915632428224,"score_spread":0.2185374193493297,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}