{"id":"W4397007698","doi":"10.3390/ijms25105480","title":"PolyI:C Maternal Immune Activation on E9.5 Causes the Deregulation of Microglia and the Complement System in Mice, Leading to Decreased Synaptic Spine Density","year":2024,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto; University of New Brunswick; Centre for Addiction and Mental Health","funders":"Canadian Institutes of Health Research","keywords":"Synaptic pruning; Microglia; Dendritic spine; Neuroscience; Biology; Immune system; Synaptic plasticity; Synapse; Immunology; Inflammation; Genetics; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002060536,0.0007054933,0.0003022389,0.001036518,0.00028084,0.0004597779,0.0004764825,0.0008299667,0.002987423],"category_scores_gemma":[0.0002103224,0.0002995795,0.000396236,0.0002644685,0.0006513374,0.0003659544,0.0003588473,0.001696809,0.0006151482],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008106584,"about_ca_system_score_gemma":0.0003593697,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00166573,"about_ca_topic_score_gemma":0.003637314,"domain_scores_codex":[0.9994857,0.00005269722,0.00005911317,0.0001516902,0.0001332479,0.0001175352],"domain_scores_gemma":[0.9994708,0.0000651225,0.0002396636,0.00005057772,0.00003422955,0.0001396771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002035375,0.00007221797,0.0002241491,0.00003146183,0.000007151522,0.0001303382,0.00001817703,0.0000463807,0.9981395,0.0001920499,0.00005295499,0.0008820275],"study_design_scores_gemma":[0.00001999274,0.0004039098,0.007646052,0.00002000412,0.0000195061,0.0002956176,0.0000487376,0.0005467942,0.9890855,0.0001205156,0.001785029,0.000008311266],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843061,0.001689375,0.006901264,0.0004286334,0.0001560907,0.0001033996,0.002786105,0.0002643526,0.003364659],"genre_scores_gemma":[0.9761338,0.001569755,0.006869389,0.0002540649,0.00002629223,0.0002319406,0.001755268,0.0001466678,0.01301276],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002987423,"threshold_uncertainty_score":0.009993911,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02504689083757026,"score_gpt":0.2914549880331037,"score_spread":0.2664080971955334,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}