{"id":"W4397010883","doi":"10.1186/s10194-024-01778-3","title":"Alleviation of migraine related pain and anxiety by inhibiting calcium-stimulating AC1-dependent CGRP in the insula of adult rats","year":2024,"lang":"en","type":"article","venue":"The Journal of Headache and Pain","topic":"Migraine and Headache Studies","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Natural Science Foundation of China","keywords":"Calcitonin gene-related peptide; Migraine; Elevated plus maze; Nociception; Glutamate receptor; Endocrinology; Medicine; Internal medicine; Open field; Neurotransmission; NMDA receptor; Excitatory postsynaptic potential; Neuroscience; Receptor; Neuropeptide; Psychology; Anxiety; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001327972,0.0008429262,0.0005183936,0.0004524453,0.0002001386,0.0001911847,0.0002932065,0.0002762967,0.001607712],"category_scores_gemma":[0.0001110329,0.0001964713,0.000442009,0.0001762117,0.0004426137,0.0002993437,0.0001965001,0.0008892532,0.0003216769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003645908,"about_ca_system_score_gemma":0.0003670027,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001308204,"about_ca_topic_score_gemma":0.002547729,"domain_scores_codex":[0.9999095,0.000006699518,0.000006510577,0.00001886847,0.00002247082,0.00003585369],"domain_scores_gemma":[0.9998996,0.000005585864,0.00003829997,0.000009458622,0.000009254612,0.00003776755],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001384721,0.0001682481,0.0002642014,0.0001434403,0.00001741262,0.0001060082,0.00003473712,0.00005840926,0.9929178,0.00009236651,0.0001405861,0.004672039],"study_design_scores_gemma":[0.0004293787,0.006781815,0.02222639,0.0000408659,0.0001737234,0.0005246403,0.0001243331,0.0009750611,0.9654211,0.0001523887,0.003130927,0.00001934757],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922445,0.003208044,0.002245528,0.0002934889,0.00005614517,0.00005596234,0.0005355359,0.0001678085,0.001192889],"genre_scores_gemma":[0.9887079,0.003990071,0.003841798,0.0001586385,0.00005153373,0.0001842536,0.0007993291,0.00002568917,0.00224077],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001607712,"threshold_uncertainty_score":0.005378366,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01870420907765427,"score_gpt":0.2882295536024436,"score_spread":0.2695253445247893,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}