{"id":"W4397029865","doi":"10.1101/2024.05.15.594354","title":"Netrin G1 Ligand is a new stromal immunomodulator that promotes pancreatic cancer","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pancreas Centre (Canada)","funders":"","keywords":"Pancreatic cancer; Stromal cell; Netrin; Cancer research; Ligand (biochemistry); Chemistry; Cancer; Cell biology; Medicine; Internal medicine; Biology; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003039773,0.0008561548,0.0006283906,0.000164461,0.0001204875,0.0003757495,0.0008650355,0.0008635112,0.00009927532],"category_scores_gemma":[0.0001809436,0.0009000251,0.0003904108,0.0003244189,0.0001367535,0.000008901794,0.001418823,0.0007512749,0.00008882047],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001810823,"about_ca_system_score_gemma":0.002902053,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000278955,"about_ca_topic_score_gemma":0.000006348517,"domain_scores_codex":[0.9964864,0.00009761062,0.0005166823,0.001702557,0.0004531464,0.0007436647],"domain_scores_gemma":[0.9969559,0.00002258869,0.0003319374,0.001928538,0.00025604,0.0005050068],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008988259,0.00009795165,0.009212214,0.0006402311,0.0007395723,0.00006535737,0.00001644757,0.00003594936,0.9846974,0.00004084207,0.00435512,0.000009010408],"study_design_scores_gemma":[0.0005525903,0.0001243225,0.01046211,0.0009060074,0.0004540248,5.927294e-8,0.000002313978,0.0001461306,0.9801176,0.00001705023,0.006203122,0.001014697],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9577137,0.03797032,0.0001998657,0.0003533319,0.001707581,0.0008700288,0.000933147,0.0002426192,0.000009422688],"genre_scores_gemma":[0.994601,0.000710335,0.001711302,0.000352914,0.001851739,0.0003431294,0.000003383812,0.0002916881,0.0001345563],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03725998,"threshold_uncertainty_score":0.9993451,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01613029908577751,"score_gpt":0.2398514148459193,"score_spread":0.2237211157601418,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}