{"id":"W4397034762","doi":"10.1002/cbic.202400226","title":"Monomer‐Dimer Equilibrium of Human Cystatin C During Internalization Into Cancer Cells","year":2024,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Biomedical Research and Pathophysiology","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Narodowym Centrum Nauki; Narodowe Centrum Nauki","keywords":"Internalization; Extracellular; Endocytosis; Chemistry; HeLa; Cell biology; Dimer; Biochemistry; Cysteine; Cancer cell; Transmembrane protein; Proteases; Biophysics; Cell; Biology; Cancer; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001866707,0.0001479129,0.0001918587,0.0001527414,0.0002188812,0.0003517515,0.0002270661,0.000278742,0.0008926339],"category_scores_gemma":[0.0002080019,0.0001239824,0.0001945531,0.0001107121,0.0001657349,0.0003795637,0.0001583436,0.0004499637,0.00031062],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005300185,"about_ca_system_score_gemma":0.0002490836,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002033055,"about_ca_topic_score_gemma":0.001066944,"domain_scores_codex":[0.9998344,0.00002482933,0.00000812188,0.00004940158,0.00003925704,0.00004404999],"domain_scores_gemma":[0.9999174,0.00002010156,0.00001292592,0.00001138778,0.00002616233,0.0000121207],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008625339,0.00001798799,0.0003611514,0.00002464832,0.000005835754,0.00004268403,0.00008471362,0.00009538589,0.9981516,0.0003075062,0.00004873675,0.000773381],"study_design_scores_gemma":[0.000007666576,0.00008422154,0.003222221,0.000004831073,0.000009101012,0.0001591304,0.00007699199,0.003047838,0.9921558,0.00009122687,0.001133698,0.000007271496],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940149,0.0007275471,0.003342811,0.00006113058,0.000009995714,0.00002030593,0.00007219827,0.00002733835,0.001723786],"genre_scores_gemma":[0.9961378,0.0002517457,0.001746697,0.00003719324,0.000002949902,0.00001417034,0.0001408369,0.00001666889,0.001651866],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002033055,"threshold_uncertainty_score":0.004042447,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01954425205285677,"score_gpt":0.358713216741106,"score_spread":0.3391689646882492,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}