{"id":"W4397039886","doi":"10.1038/s41398-024-02915-x","title":"The circulating proteome and brain health: Mendelian randomisation and cross-sectional analyses","year":2024,"lang":"en","type":"article","venue":"Translational Psychiatry","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Thrombosis and Atherosclerosis Research Institute; University of Calgary; Hamilton Health Sciences; McMaster University; Population Health Research Institute","funders":"Canadian Institutes of Health Research; Wellcome Trust; Lister Institute of Preventive Medicine; Government of Canada; Medical Research Council; Wellcome; Heart and Stroke Foundation of Canada","keywords":"Digit symbol substitution test; Cognition; Dementia; Effects of sleep deprivation on cognitive performance; Cohort; Medicine; Cognitive decline; Stroke (engine); Neuropsychology; Psychology; Internal medicine; Psychiatry; Pathology; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01039169,0.0007439672,0.0009238639,0.0009417949,0.0006712666,0.0007464347,0.0008761207,0.0008475262,0.002321567],"category_scores_gemma":[0.01400144,0.000516577,0.001362416,0.001429822,0.0006296703,0.0003904436,0.0006192261,0.0006670798,0.0002687341],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003862477,"about_ca_system_score_gemma":0.0003758701,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004301901,"about_ca_topic_score_gemma":0.002664367,"domain_scores_codex":[0.9914697,0.005312489,0.0004947715,0.001767985,0.0006297922,0.000325196],"domain_scores_gemma":[0.9937458,0.002512699,0.0008805345,0.00235779,0.0003143352,0.0001889],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01486451,0.0003222874,0.9475505,0.0002086481,0.00960464,0.00129872,0.0008509243,0.001452206,0.007490106,0.002328263,0.00131164,0.01271755],"study_design_scores_gemma":[0.001161922,0.003056321,0.9693569,0.00004039662,0.004422212,0.001972869,0.0002430306,0.01251699,0.002000871,0.002092912,0.003076643,0.00005890243],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9792539,0.0008434235,0.01788248,0.00008522951,0.00005905872,0.0002727363,0.001007844,0.0000772377,0.0005180523],"genre_scores_gemma":[0.9941876,0.0001288997,0.004136113,0.00005604034,0.00001872612,0.0003032833,0.0006337501,0.0000331585,0.0005025405],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01039169,"threshold_uncertainty_score":0.05495721,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04113412313742643,"score_gpt":0.3830567737841277,"score_spread":0.3419226506467013,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}