{"id":"W4397041272","doi":"10.1681/asn.20233411s1575a","title":"ABCC6 and CKD: The Phenotypic Expansion of Pseudoxanthoma Elasticum","year":2023,"lang":"en","type":"article","venue":"Journal of the American Society of Nephrology","topic":"Dermatological and Skeletal Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; Western University","funders":"","keywords":"Pseudoxanthoma elasticum; Medicine; Phenotype; Dermatology; Pathology; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002086254,0.00008174044,0.0002565384,0.00001470239,0.00006199049,0.000002987243,0.0002801072,0.00005845664,0.000004923683],"category_scores_gemma":[0.00006116225,0.00004162339,0.000287592,0.0001910869,0.001084693,0.00000287806,0.0001693452,0.0001254649,9.274409e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002661561,"about_ca_system_score_gemma":0.00003917698,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001113036,"about_ca_topic_score_gemma":0.000001935033,"domain_scores_codex":[0.9992515,0.000117762,0.0002720043,0.00008909264,0.0001263918,0.0001432346],"domain_scores_gemma":[0.9991254,0.00007990506,0.0005173841,0.000164469,0.00008129366,0.00003155448],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001456106,0.00003451131,0.003022176,0.0000191109,0.0001599641,0.000001115067,0.0001845809,0.00008910027,0.9576758,0.00005345786,0.03500191,0.003612654],"study_design_scores_gemma":[0.001607886,0.00259585,0.8653864,0.00004102632,0.0002119223,0.0004736927,0.00537941,0.0007043446,0.05636881,0.003297656,0.06366083,0.0002721894],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941382,0.000417549,0.0002790683,0.004983916,0.00006425363,0.00004922797,0.00000390444,0.000002300297,0.00006154689],"genre_scores_gemma":[0.9956494,0.001277426,0.0003688183,0.002565716,0.00006554685,0.00000106711,0.00000110062,0.000006237325,0.00006470655],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.901307,"threshold_uncertainty_score":0.3996595,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009226402705790001,"score_gpt":0.2461583690967475,"score_spread":0.2369319663909575,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}