{"id":"W4397041612","doi":"10.1681/asn.20233411s1482a","title":"A Case of Acute Interstitial Nephritis Associated with Belvarafenib, a Novel pan-RAF Kinase Inhibitor for Metastatic NRAS Mutant Melanoma","year":2023,"lang":"en","type":"article","venue":"Journal of the American Society of Nephrology","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"Neuroblastoma RAS viral oncogene homolog; Cancer research; Mutant; Medicine; Melanoma; Metastatic melanoma; Kinase; Interstitial nephritis; Internal medicine; Cancer; Biology; Colorectal cancer; Kidney; Cell biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005535307,0.001703686,0.001126285,0.002347092,0.002129785,0.001461012,0.001556843,0.00410339,0.002460232],"category_scores_gemma":[0.002596481,0.001343081,0.001367722,0.001341267,0.00130215,0.002136421,0.00141713,0.003232878,0.0007034731],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00145822,"about_ca_system_score_gemma":0.001052206,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002646409,"about_ca_topic_score_gemma":0.003380514,"domain_scores_codex":[0.9989561,0.0001259996,0.00010167,0.0002813932,0.0001769614,0.0003578538],"domain_scores_gemma":[0.9978487,0.0004763094,0.000523744,0.0002315231,0.0001668784,0.0007527417],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.00005798531,0.00003709177,0.003827063,0.0000445356,0.00001140036,0.9941755,0.000113807,0.00004228042,0.0008055055,0.0000949466,0.0001264029,0.0006634782],"study_design_scores_gemma":[0.00001734564,0.00006343894,0.002554105,0.00001099011,0.00001384847,0.9962794,0.00006430229,0.0002096549,0.0003654228,0.0000529454,0.0003620003,0.000006583079],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9530886,0.01370766,0.009379441,0.003161312,0.0005561615,0.0004074533,0.0003261314,0.0006012605,0.01877192],"genre_scores_gemma":[0.995303,0.001224142,0.001210094,0.0005573501,0.0004712109,0.00002440521,0.00008731827,0.00002195596,0.001100488],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00410339,"threshold_uncertainty_score":0.01058012,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0185947873200485,"score_gpt":0.26523894046757,"score_spread":0.2466441531475215,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}