{"id":"W4397041788","doi":"10.1681/asn.20233411s1473c","title":"Clonal Hematopoiesis of Indeterminate Potential Is Associated with Kidney Disease Progression in a Multi-Cohort Meta-Analysis of Individuals with CKD","year":2023,"lang":"en","type":"article","venue":"Journal of the American Society of Nephrology","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; University of British Columbia; Queen's University","funders":"","keywords":"Meta-analysis; Indeterminate; Cohort; Kidney disease; Medicine; Internal medicine; Disease; Haematopoiesis; Cohort study; Oncology; Immunology; Biology; Stem cell; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006040186,0.001142494,0.003414534,0.001772505,0.000827809,0.001924576,0.001202648,0.001065064,0.001684522],"category_scores_gemma":[0.007520935,0.0007777002,0.01525951,0.002870281,0.0003783079,0.0006175148,0.001174537,0.001458067,0.0001314555],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005087992,"about_ca_system_score_gemma":0.0007751834,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008601638,"about_ca_topic_score_gemma":0.0113768,"domain_scores_codex":[0.9966696,0.00151124,0.0003904933,0.0008988958,0.0003085373,0.0002212024],"domain_scores_gemma":[0.9932125,0.00383474,0.001078893,0.001017922,0.0005500602,0.0003059047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.006108945,0.00004759958,0.6132824,0.003685596,0.3667903,0.000246579,0.0001017228,0.001755478,0.0008282628,0.0001629662,0.0009701231,0.00602003],"study_design_scores_gemma":[0.0005509272,0.0004104648,0.4777482,0.0005752947,0.5133496,0.0004781921,0.0001015373,0.003827648,0.0004088837,0.0005739553,0.001924849,0.00005045855],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7213314,0.2652352,0.004282426,0.0009313188,0.0003573743,0.0001013389,0.006323872,0.0001690004,0.001268165],"genre_scores_gemma":[0.989543,0.007824148,0.0007193995,0.0001708632,0.00008754664,0.00006859646,0.001328326,0.00002505033,0.0002330846],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008601638,"threshold_uncertainty_score":0.03194392,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03719378794538453,"score_gpt":0.3282201334575187,"score_spread":0.2910263455121342,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}