{"id":"W4397042281","doi":"10.1681/asn.20233411s1974a","title":"IMAGINATION: A Global Phase 3 Trial of RO7434656, an Antisense Oligonucleotide Inhibitor of Complement Factor B, in IgA Nephropathy","year":2023,"lang":"en","type":"article","venue":"Journal of the American Society of Nephrology","topic":"Renal Diseases and Glomerulopathies","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"","keywords":"Factor H; Complement (music); Nephropathy; Complement system; Alternative complement pathway; Medicine; Phase (matter); Internal medicine; Immunology; Endocrinology; Antibody; Chemistry; Gene; Biology; Genetics; Phenotype; Diabetes mellitus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001363212,0.001792194,0.001245774,0.0004711564,0.0003064169,0.0008023488,0.0008612797,0.001102503,0.004621948],"category_scores_gemma":[0.0004652736,0.0003040864,0.001191737,0.0002577871,0.0008852164,0.0005788035,0.0003571814,0.002615949,0.0008617037],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007505786,"about_ca_system_score_gemma":0.001215607,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00096364,"about_ca_topic_score_gemma":0.003308025,"domain_scores_codex":[0.9996423,0.0001712078,0.00001153866,0.00005768768,0.00003376877,0.00008350004],"domain_scores_gemma":[0.9996706,0.00004552321,0.00007826369,0.00002001077,0.00001955745,0.0001659857],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.687824,0.04633642,0.004819733,0.001871741,0.00148757,0.0004058231,0.0003588591,0.002183227,0.1023025,0.000906356,0.01552464,0.1359791],"study_design_scores_gemma":[0.7078112,0.271669,0.008477092,0.00007171018,0.0005587008,0.0002457285,0.00006260879,0.0006256693,0.005442774,0.000306415,0.004693443,0.00003570834],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9786336,0.006242395,0.001163691,0.001748611,0.0002741496,0.003451065,0.002467607,0.0005911817,0.005427639],"genre_scores_gemma":[0.9800805,0.002717959,0.002887154,0.003179475,0.0003556357,0.002473381,0.003775735,0.00007894823,0.004451229],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004621948,"threshold_uncertainty_score":0.01546198,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02778665019412218,"score_gpt":0.3530181126833274,"score_spread":0.3252314624892052,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}