{"id":"W4397042453","doi":"10.1016/j.molmed.2024.04.014","title":"CRISPR/Cas9 screening: unraveling cancer immunotherapy’s ‘Rosetta Stone’","year":2024,"lang":"en","type":"review","venue":"Trends in Molecular Medicine","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"CRISPR; Immunotherapy; Cas9; Computational biology; Genome editing; Cancer; Cancer immunotherapy; Biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003888192,0.0007723292,0.001387249,0.000681774,0.00003280828,0.00002719839,0.0005172266,0.0005670611,0.0001248512],"category_scores_gemma":[0.000052356,0.0006190507,0.000489191,0.0007960225,0.000126576,0.000002214048,0.0001951823,0.0006907622,0.00001010604],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006638332,"about_ca_system_score_gemma":0.0001185497,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001360865,"about_ca_topic_score_gemma":0.00005501481,"domain_scores_codex":[0.9972154,0.0001120512,0.0008169006,0.000943439,0.0003484782,0.0005636881],"domain_scores_gemma":[0.9987779,0.00001809777,0.0001547766,0.0008601159,0.0000458452,0.000143219],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001117167,0.00002237702,0.000002324977,0.002336308,0.0004395262,0.0001772621,0.00007648824,0.0001546728,0.00635861,0.00002592943,0.004279671,0.9861156],"study_design_scores_gemma":[0.0005347477,0.0001598742,0.000008033522,0.008763948,0.0007880271,0.00008417315,0.00002625829,0.00006620355,0.0008344527,0.00000980858,0.9881036,0.0006209289],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00002665602,0.9847749,0.0131971,0.0002074791,0.0008592117,0.0002598044,0.00004350679,0.00007131455,0.0005600692],"genre_scores_gemma":[0.0002426612,0.9947215,0.0008147407,0.0002115606,0.0008456344,0.0001744209,0.0006586373,0.0003185095,0.002012286],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9854947,"threshold_uncertainty_score":0.9996261,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0358293421115649,"score_gpt":0.4307978710365217,"score_spread":0.3949685289249568,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}