{"id":"W4397042453","doi":"10.1016/j.molmed.2024.04.014","title":"CRISPR/Cas9 screening: unraveling cancer immunotherapy’s ‘Rosetta Stone’","year":2024,"lang":"en","type":"review","venue":"Trends in Molecular Medicine","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"CRISPR; Immunotherapy; Cas9; Computational biology; Genome editing; Cancer; Cancer immunotherapy; Biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006612319,0.0006809683,0.0009800498,0.001995353,0.0002360638,0.00108086,0.0008219104,0.0009951958,0.002070182],"category_scores_gemma":[0.0005586415,0.0002845687,0.000491056,0.001514124,0.0005365336,0.001264877,0.0005852141,0.002066175,0.001578959],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006348127,"about_ca_system_score_gemma":0.001061776,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009463009,"about_ca_topic_score_gemma":0.001426416,"domain_scores_codex":[0.9997671,0.00003591531,0.00002138217,0.00004260269,0.0001073659,0.00002567474],"domain_scores_gemma":[0.9997281,0.0001308132,0.00002595807,0.000009503181,0.00007598888,0.00002950285],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004981471,0.00005498504,0.0001441329,0.007669956,0.00006152691,0.0002296576,0.00005889658,0.0005258655,0.01082807,0.0109585,0.02644616,0.9429725],"study_design_scores_gemma":[0.00001057104,0.00008401065,0.000396211,0.001218299,0.00005605883,0.0009054463,0.00004414988,0.0002513214,0.004239872,0.003755257,0.989011,0.00002774161],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004711156,0.9931733,0.001900164,0.001008988,0.0003489877,0.00001280238,0.00005645185,0.00005377952,0.002974467],"genre_scores_gemma":[0.002300374,0.9939557,0.001247634,0.0005766477,0.0001386971,0.0000118678,0.00009554702,0.000008825264,0.001664792],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002070182,"threshold_uncertainty_score":0.006925464,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0358293421115649,"score_gpt":0.4307978710365217,"score_spread":0.3949685289249568,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}