{"id":"W4397045234","doi":"10.1681/asn.20233411s1116c","title":"Hedgehog Interacting Protein (Hhip) Deficiency in Endothelial Cells Prevents Ischemia Reperfusion-Induced Renal Tubular Cell Injury Through Inhibition of NF-KB Signaling","year":2023,"lang":"en","type":"article","venue":"Journal of the American Society of Nephrology","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Hedgehog signaling pathway; Cancer research; Reperfusion injury; Cell biology; Chemistry; Signal transduction; Ischemia; Medicine; Pharmacology; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001515594,0.0003166729,0.0003145063,0.0001752015,0.0001456056,0.0002237163,0.000217862,0.0002570567,0.001375761],"category_scores_gemma":[0.00007646467,0.0001277547,0.0002539258,0.0001288182,0.0002540757,0.000159751,0.0001672769,0.0006819466,0.0002852956],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001631253,"about_ca_system_score_gemma":0.0002523674,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005406314,"about_ca_topic_score_gemma":0.0008121526,"domain_scores_codex":[0.9998406,0.00001739447,0.00002066454,0.00002505685,0.00004230305,0.00005398279],"domain_scores_gemma":[0.9999082,0.000007662245,0.00003142685,0.000009039108,0.000009040315,0.00003455952],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003028645,0.00009604827,0.0002506483,0.00009385061,0.0000115588,0.00004624229,0.00001315703,0.00003813067,0.997346,0.00006539906,0.0001163174,0.001619766],"study_design_scores_gemma":[0.00006296739,0.001001213,0.005564251,0.00001487965,0.00004630785,0.0002017144,0.00004201374,0.0005663651,0.9904311,0.00003300638,0.002032001,0.000004211047],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943408,0.001637331,0.001975425,0.0001249492,0.00004980603,0.0000346556,0.0005374078,0.0001437412,0.001155945],"genre_scores_gemma":[0.9926329,0.001523854,0.002171599,0.00009125665,0.00001956857,0.00008180334,0.0007403454,0.00001775192,0.002721021],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001375761,"threshold_uncertainty_score":0.004602373,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01687231761756778,"score_gpt":0.2744805215602685,"score_spread":0.2576082039427007,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}