{"id":"W4397046409","doi":"10.1681/asn.20223311s1869a","title":"Differential Expression of Renal and Hepatic PCSK9 During Development of Hypercholesterolemia in the Puromycin Aminonucleoside Nephrosis Rat Model of Nephrotic Syndrome","year":2022,"lang":"en","type":"article","venue":"Journal of the American Society of Nephrology","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"Nephrosis; Puromycin; Nephrotic syndrome; Internal medicine; Endocrinology; Medicine; Biology; Protein biosynthesis; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001647024,0.0003365712,0.0004557145,0.0008051041,0.0002245322,0.0002579117,0.0001868137,0.0003884675,0.001237185],"category_scores_gemma":[0.00009677973,0.0002797785,0.0004622108,0.0002968512,0.0003320217,0.0002559686,0.0001748072,0.0007901411,0.0004165376],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003182173,"about_ca_system_score_gemma":0.0002690815,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009433316,"about_ca_topic_score_gemma":0.001572852,"domain_scores_codex":[0.9997787,0.00001853285,0.00002196637,0.00004810669,0.00006956858,0.00006316484],"domain_scores_gemma":[0.9996898,0.0000163231,0.00008003407,0.00002621801,0.00003910124,0.0001485006],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009741621,0.0001536826,0.001211946,0.00003883785,0.00001314664,0.0002083492,0.00004320273,0.00003355601,0.9964105,0.00005916442,0.0000405413,0.0008128277],"study_design_scores_gemma":[0.00007449167,0.002140378,0.04185541,0.0000132106,0.00008333463,0.001031745,0.0001946808,0.0008566693,0.9523579,0.00006931352,0.001305164,0.00001766378],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965252,0.0007708826,0.001225644,0.00007202673,0.00003693551,0.00003281503,0.0004140264,0.00007214952,0.000850239],"genre_scores_gemma":[0.9923198,0.0008026501,0.001886994,0.00006524656,0.0000166902,0.00008506607,0.0006950964,0.00002218891,0.004106376],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001237185,"threshold_uncertainty_score":0.004138768,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01694613763218708,"score_gpt":0.2443382203914126,"score_spread":0.2273920827592255,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}