{"id":"W4397046993","doi":"10.1681/asn.20223311s1800a","title":"An Exploratory Trial of an Investigational RNA Therapeutic, IONIS-FB-LRx, for Treatment of IgA Nephropathy","year":2022,"lang":"en","type":"article","venue":"Journal of the American Society of Nephrology","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre; University of British Columbia","funders":"","keywords":"Medicine; Nephropathy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001058832,0.001401385,0.001337472,0.0002805959,0.0003371082,0.0006861996,0.0007436678,0.001307945,0.004597316],"category_scores_gemma":[0.0007524725,0.0003957589,0.0007527704,0.0001978447,0.0008335673,0.000707228,0.0003474629,0.001940845,0.0005266718],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006123619,"about_ca_system_score_gemma":0.00112174,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006122666,"about_ca_topic_score_gemma":0.001342832,"domain_scores_codex":[0.999691,0.0001457676,0.00001324119,0.00006146888,0.00002444533,0.00006407711],"domain_scores_gemma":[0.9994437,0.0001351196,0.0001144878,0.00003897161,0.00003173377,0.0002359546],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9230037,0.02561896,0.00199784,0.0003371441,0.0004744991,0.0002134206,0.0001339611,0.0004419019,0.02034558,0.0001499907,0.0006995845,0.0265835],"study_design_scores_gemma":[0.5779781,0.4137599,0.005096537,0.00002529414,0.0002540023,0.0001111823,0.00002765621,0.0004263206,0.001516229,0.00009278332,0.0007002037,0.00001162987],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958181,0.0006527579,0.0002533861,0.0003205258,0.00007261184,0.001151313,0.0003637791,0.00004267071,0.001324826],"genre_scores_gemma":[0.9942669,0.0005602047,0.0008492634,0.0005780663,0.0002058342,0.001327894,0.0005434179,0.000008756045,0.001659638],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004597316,"threshold_uncertainty_score":0.01537955,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01978764960972549,"score_gpt":0.2809986881386514,"score_spread":0.2612110385289259,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}