{"id":"W4397047040","doi":"10.1186/s13024-024-00727-7","title":"Variants in the MS4A cluster interact with soluble TREM2 expression on biomarkers of neuropathology","year":2024,"lang":"en","type":"article","venue":"Molecular Neurodegeneration","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Genentech; National Institutes of Health; UK Dementia Research Institute; IXICO; H. Lundbeck A/S; HORIZON EUROPE Framework Programme; Servier; European Commission; Familjen Erling-Perssons Stiftelse; Hjärnfonden; Vetenskapsrådet; Eisai; University of Southern California; University College London; Vanderbilt University; EU Joint Programme – Neurodegenerative Disease Research; National Institute on Aging; National Institute for Health and Care Research; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; Alzheimer's Association; Stiftelsen för Gamla Tjänarinnor; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; Alzheimer's Drug Discovery Foundation","keywords":"TREM2; Neuropathology; Neurodegeneration; Biomarker; Genome-wide association study; Neurology; Medicine; Minor allele frequency; Allele; Alzheimer's disease; Internal medicine; Bioinformatics; Disease; Neuroscience; Oncology; Biology; Genetics; Genotype; Gene; Allele frequency; Single-nucleotide polymorphism; Microglia","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003389327,0.0002490367,0.0001775044,0.0003887815,0.0001139833,0.000197421,0.0003193168,0.00006788197,0.00003847676],"category_scores_gemma":[0.0002328105,0.0001702735,0.00007910996,0.000685651,0.00006580804,0.0002966834,0.00004946535,0.0003024501,0.00004975556],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001815779,"about_ca_system_score_gemma":0.00005004583,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003148189,"about_ca_topic_score_gemma":0.000009415732,"domain_scores_codex":[0.9968117,0.001241956,0.0004317707,0.000735242,0.0005248931,0.0002543716],"domain_scores_gemma":[0.9990367,0.000245283,0.0001134056,0.0005226203,0.00003384644,0.00004817482],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001476228,0.00009300225,0.000008197849,0.00002314615,0.000001816769,0.0004573259,0.0002585617,0.006842483,0.9811984,0.009714234,0.0004459168,0.0008092617],"study_design_scores_gemma":[0.0004348464,0.0004593357,0.0001577965,0.00005281765,0.00001107158,0.0002068527,0.00001070348,0.0355532,0.9621165,0.0001710888,0.0006732377,0.000152585],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9771131,0.0000225558,0.01767636,0.002367278,0.0008685457,0.0006024606,0.000008185708,0.0001136989,0.001227828],"genre_scores_gemma":[0.9946443,0.00002114562,0.0002364198,0.004766018,0.00005899135,0.00005934939,0.00001374428,0.00005196651,0.0001481008],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02871072,"threshold_uncertainty_score":0.6943552,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02053227587264139,"score_gpt":0.2591298496159726,"score_spread":0.2385975737433312,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}