{"id":"W4397047970","doi":"10.1681/asn.20223311s1967c","title":"A Phase 1b, Multicenter, Open-Label Study to Evaluate the Safety, Pharmacokinetics, and Efficacy of Tegoprubart (AT-1501) in Patients Undergoing Kidney Transplant","year":2022,"lang":"en","type":"article","venue":"Journal of the American Society of Nephrology","topic":"Pharmacological Effects and Toxicity Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; Vancouver General Hospital; McGill University Health Centre","funders":"","keywords":"Pharmacokinetics; Medicine; Open label; Multicenter study; Kidney transplantation; Kidney transplant; Internal medicine; Kidney; Intensive care medicine; Adverse effect; Urology; Pharmacology; Randomized controlled trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003676121,0.00175363,0.002644697,0.0003789896,0.0008197625,0.001253764,0.0008380185,0.001567545,0.007053145],"category_scores_gemma":[0.002036225,0.0007017229,0.001566326,0.0004503338,0.001305279,0.00160082,0.0005403254,0.003485308,0.001488933],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009501065,"about_ca_system_score_gemma":0.002855077,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006594094,"about_ca_topic_score_gemma":0.001062973,"domain_scores_codex":[0.998995,0.0004763261,0.00006048148,0.0002092676,0.00008936401,0.0001695432],"domain_scores_gemma":[0.9975147,0.0003394838,0.0004817326,0.0002207785,0.0001935956,0.001249759],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8186364,0.1159727,0.009375164,0.0005744687,0.001046166,0.0001909765,0.0002679849,0.0006511564,0.02069698,0.0001357044,0.001988785,0.03046352],"study_design_scores_gemma":[0.4115669,0.5758289,0.009376996,0.00001811031,0.0002776029,0.0001440075,0.00005412145,0.0003978712,0.001029193,0.0001109055,0.001176211,0.00001920968],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901587,0.001090951,0.000804398,0.00042675,0.0001431211,0.005193336,0.001269682,0.00007300435,0.0008399941],"genre_scores_gemma":[0.9807402,0.0009701348,0.003157202,0.001766947,0.0003505773,0.008301457,0.002504333,0.00004044469,0.002168787],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007053145,"threshold_uncertainty_score":0.02359509,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03949499356665214,"score_gpt":0.373716235134364,"score_spread":0.3342212415677119,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}