{"id":"W4398134337","doi":"10.1016/j.jaad.2024.05.023","title":"Tapinarof cream 1% once daily: Significant efficacy in the treatment of moderate to severe atopic dermatitis in adults and children down to 2 years of age in the pivotal phase 3 ADORING trials","year":2024,"lang":"en","type":"article","venue":"Journal of the American Academy of Dermatology","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research; University of Toronto; Innovaderm (Canada)","funders":"Allergan; Genentech; Galderma; Astellas Pharma; Meiji Seika Pharma; Pfizer; Biogen; Incyte; Boston Pharmaceuticals; Castle Biosciences; Sun Pharma; Dermira; Les Laboratories Pierre Fabre; Coherus Biosciences; UCB Pharma; Valeant Pharmaceuticals International; Baxalta; Celgene; Ablynx; LEO Pharma; Ortho Dermatologics; Gilead Sciences; GlaxoSmithKline; Astellas Pharma US; Amgen; Eli Lilly and Company; Bristol-Myers Squibb; Bausch Health; Bayer HealthCare; Sanofi; Regeneron Pharmaceuticals; Abbott Laboratories","keywords":"Medicine; Atopic dermatitis; Dermatology; Pediatrics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001554004,0.0005423581,0.001210848,0.0002295975,0.0002074959,0.0007056581,0.0003504647,0.0007426377,0.003470188],"category_scores_gemma":[0.0008868103,0.0002030541,0.001199748,0.0002256849,0.0002728967,0.0004639052,0.0001637397,0.001157153,0.0002960949],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003651205,"about_ca_system_score_gemma":0.0004343958,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003592121,"about_ca_topic_score_gemma":0.001874909,"domain_scores_codex":[0.9996921,0.0001216091,0.00002716432,0.0000470686,0.00005891155,0.00005321408],"domain_scores_gemma":[0.9994005,0.0001757842,0.0002174849,0.0000172639,0.00006003906,0.0001290336],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.450716,0.008895968,0.01115788,0.01240845,0.003965294,0.0005610963,0.000418933,0.001033304,0.05250027,0.0007356508,0.01332032,0.4442869],"study_design_scores_gemma":[0.6215819,0.2846199,0.05679857,0.001682647,0.003301486,0.001631188,0.0001589895,0.001064878,0.006554149,0.0005461046,0.02198612,0.00007418572],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8755626,0.1146469,0.0008626875,0.001117661,0.0003494684,0.001433948,0.001271597,0.0001414629,0.004613718],"genre_scores_gemma":[0.9645376,0.02961101,0.001448707,0.001056901,0.0002740927,0.0007523973,0.00096921,0.0000195743,0.001330591],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003470188,"threshold_uncertainty_score":0.0116089,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02424207421711915,"score_gpt":0.3487968293378055,"score_spread":0.3245547551206864,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}