{"id":"W4398134337","doi":"10.1016/j.jaad.2024.05.023","title":"Tapinarof cream 1% once daily: Significant efficacy in the treatment of moderate to severe atopic dermatitis in adults and children down to 2 years of age in the pivotal phase 3 ADORING trials","year":2024,"lang":"en","type":"article","venue":"Journal of the American Academy of Dermatology","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research; University of Toronto; Innovaderm (Canada)","funders":"Allergan; Genentech; Galderma; Astellas Pharma; Meiji Seika Pharma; Pfizer; Biogen; Incyte; Boston Pharmaceuticals; Castle Biosciences; Sun Pharma; Dermira; Les Laboratories Pierre Fabre; Coherus Biosciences; UCB Pharma; Valeant Pharmaceuticals International; Baxalta; Celgene; Ablynx; LEO Pharma; Ortho Dermatologics; Gilead Sciences; GlaxoSmithKline; Astellas Pharma US; Amgen; Eli Lilly and Company; Bristol-Myers Squibb; Bausch Health; Bayer HealthCare; Sanofi; Regeneron Pharmaceuticals; Abbott Laboratories","keywords":"Medicine; Atopic dermatitis; Dermatology; Pediatrics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005001627,0.0001577027,0.001177889,0.0004052597,0.00002273781,0.000008946695,0.0003623086,0.00007594625,0.000004335601],"category_scores_gemma":[0.0003795162,0.000085659,0.000198395,0.0006129337,0.0003276416,0.00006958129,0.0000434284,0.00035557,0.000001299563],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004484748,"about_ca_system_score_gemma":0.0001051071,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001251294,"about_ca_topic_score_gemma":0.00002077354,"domain_scores_codex":[0.9972306,0.0009759383,0.001147161,0.0001615901,0.000259718,0.0002249641],"domain_scores_gemma":[0.9979603,0.001213498,0.000554539,0.0001742599,0.00002166137,0.00007573218],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01493241,0.01142576,0.6858103,0.001130083,0.001664561,0.006935857,0.1057765,0.001964065,0.0071278,0.000891112,0.009417679,0.1529239],"study_design_scores_gemma":[0.006282758,0.0009614088,0.9787877,0.001286761,0.0002319905,0.005260366,0.002173811,0.0001147034,0.004077865,0.0002316674,0.0004776967,0.0001132461],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9798785,0.002184249,0.00001025717,0.01711737,0.00004500305,0.0006965179,0.00002827659,0.00000317645,0.00003667287],"genre_scores_gemma":[0.9975782,0.0009469089,0.0001391592,0.001265099,0.0000369788,0.0000183727,0.000001517836,0.000009587276,0.000004192349],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2929775,"threshold_uncertainty_score":0.3493073,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02424207421711915,"score_gpt":0.3487968293378055,"score_spread":0.3245547551206864,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}