{"id":"W4398135543","doi":"10.21203/rs.3.rs-4387915/v1","title":"Inhibition of Wnt/β-catenin Signaling Pathway via XAV939 does not mitigate Dextran Sulfate Sodium-Induced Ulcerative Colitis Running Title: XAV939 does not mitigate Ulcerative Colitis","year":2024,"lang":"en","type":"preprint","venue":"Research Square","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute","funders":"","keywords":"Ulcerative colitis; Colitis; Wnt signaling pathway; Chemistry; Gastroenterology; Medicine; Internal medicine; Signal transduction; Biochemistry; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001748082,0.0003802744,0.0005820254,0.0003342837,0.000178365,0.0006324553,0.0003176132,0.00061588,0.005684106],"category_scores_gemma":[0.0001674449,0.0001300767,0.000340562,0.000343458,0.0002350428,0.0003466596,0.0001983772,0.0009940952,0.001777732],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002177723,"about_ca_system_score_gemma":0.0003151114,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005187896,"about_ca_topic_score_gemma":0.0005736998,"domain_scores_codex":[0.9997972,0.00002337499,0.00002686099,0.00003360905,0.00008070469,0.00003839533],"domain_scores_gemma":[0.9998736,0.00001722558,0.00003823055,0.00001391102,0.00002047909,0.00003641923],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001196416,0.0001957172,0.0002825874,0.000307673,0.0000391812,0.0001643687,0.0000267072,0.0001229746,0.9874862,0.0004872615,0.0007634969,0.008927542],"study_design_scores_gemma":[0.00005642335,0.0005097967,0.002976056,0.00002958195,0.00004296292,0.0002268422,0.000037599,0.0005442867,0.9810743,0.000100701,0.01439521,0.000006394606],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9558138,0.01422594,0.01125695,0.002079078,0.001366891,0.0001165487,0.003593385,0.00118338,0.01036409],"genre_scores_gemma":[0.9376623,0.01008684,0.009039051,0.0005039572,0.000181411,0.000102554,0.004143054,0.0003381414,0.03794269],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005684106,"threshold_uncertainty_score":0.01901525,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02744918200882248,"score_gpt":0.317533824530849,"score_spread":0.2900846425220265,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}