{"id":"W4398141205","doi":"10.1038/s41582-024-00961-z","title":"The Miami Framework for ALS and related neurodegenerative disorders: an integrated view of phenotype and biology","year":2024,"lang":"en","type":"review","venue":"Nature Reviews Neurology","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; McGill University; Montreal Neurological Institute and Hospital","funders":"National Institute of Mental Health; National Institutes of Health; Mitsubishi Tanabe Pharma Corporation; Deutsche Gesellschaft für Muskelkranke; National Institute of Neurological Disorders and Stroke; Umeå Universitet; Bundesministerium für Bildung und Forschung; National Institute on Aging; Ionis Pharmaceuticals; Regeneron Pharmaceuticals; Alexion Pharmaceuticals; Medical Research Council; Biogen; Motor Neurone Disease Association; Novartis Pharma; Muscular Dystrophy Association; Cytokinetics; Sanofi; Deutsche Forschungsgemeinschaft; Apellis Pharmaceuticals; Eli Lilly and Company","keywords":"Frontotemporal dementia; Amyotrophic lateral sclerosis; Neurodegeneration; Disease; Neuroscience; Phenotype; Biomarker; Endophenotype; Prodrome; C9orf72; Dementia; Clinical phenotype; Medicine; Bioinformatics; Psychology; Biology; Pathology; Genetics; Psychiatry; Cognition; Psychosis; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002457391,0.00152837,0.002272487,0.003291747,0.0004925533,0.002614795,0.002145082,0.002916768,0.00262481],"category_scores_gemma":[0.001921323,0.0003783487,0.0007027435,0.002580698,0.002471531,0.004978468,0.002307529,0.005464784,0.001869004],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002092402,"about_ca_system_score_gemma":0.003271004,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002030934,"about_ca_topic_score_gemma":0.003743259,"domain_scores_codex":[0.9995381,0.0001277504,0.00005884908,0.00005842108,0.0001742781,0.00004258773],"domain_scores_gemma":[0.9992728,0.0003828819,0.0000583568,0.00002523835,0.0001790356,0.00008173718],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001253029,0.00006302659,0.0001895408,0.01228652,0.000150404,0.0003787863,0.0002405395,0.0005976189,0.001873251,0.07968061,0.1182743,0.78614],"study_design_scores_gemma":[0.00001456313,0.00003901327,0.0002255428,0.002691068,0.00005705149,0.0005123297,0.00006626602,0.00008712324,0.0001169065,0.01613947,0.9800306,0.00001999369],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00002877377,0.9966248,0.0004527164,0.001579617,0.0005743011,0.000002853005,0.00001251743,0.00001155419,0.0007128154],"genre_scores_gemma":[0.0004296432,0.9958359,0.0007396821,0.001489716,0.0008429702,0.00001082909,0.00002656483,0.000004090265,0.0006206271],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003291747,"threshold_uncertainty_score":0.01518154,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07548193787899246,"score_gpt":0.4380860624772144,"score_spread":0.3626041245982219,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}