{"id":"W4398142705","doi":"10.1021/acs.jproteome.4c00112","title":"Secretome of Cancer-Associated Fibroblasts (CAFs) Influences Drug Sensitivity in Cancer Cells","year":2024,"lang":"en","type":"article","venue":"Journal of Proteome Research","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Cancer Research; National Institute for Health and Care Research; Cancer Research UK; Royal Marsden NHS Foundation Trust","keywords":"Stromal cell; Cancer; Pancreatic cancer; Cancer-Associated Fibroblasts; Cancer cell; Cancer research; KRAS; Biology; Colorectal cancer; Cell culture; Stroma; Wnt signaling pathway; Cell biology; Immunology; Genetics; Signal transduction; Immunohistochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0030266,0.0001254787,0.0002602133,0.0003393305,0.00004967494,0.00004888756,0.0002386758,0.0001447238,0.0001047306],"category_scores_gemma":[0.0001492573,0.0001021886,0.0001124797,0.0006597063,0.0001591813,0.00001847343,0.00012623,0.0005430902,0.000003657651],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001880342,"about_ca_system_score_gemma":0.001317741,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009165082,"about_ca_topic_score_gemma":0.0009358973,"domain_scores_codex":[0.9979395,0.0002918354,0.0004609708,0.0002265056,0.0007049522,0.0003761859],"domain_scores_gemma":[0.9988742,0.00008247751,0.0001669009,0.0001172592,0.0006639861,0.00009515833],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001607978,0.00005219045,0.01541912,0.0002090648,0.0001480491,0.00006071828,0.000333795,0.00072518,0.9783627,0.000003715222,0.003167517,0.001357156],"study_design_scores_gemma":[0.0003646613,0.0002216577,0.01240232,0.001102684,0.00001109318,0.000006709485,0.0001193739,0.0001745164,0.9827579,0.000154783,0.002551529,0.0001328132],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913803,0.007520817,0.00002088235,0.0004731704,0.0002544773,0.0002250065,0.00002716764,0.000004099572,0.00009412684],"genre_scores_gemma":[0.9957752,0.002588036,0.0001764147,0.0000152668,0.0003122276,0.00003658642,0.000003516543,0.00002028197,0.001072517],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004932781,"threshold_uncertainty_score":0.4167132,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03982840739056967,"score_gpt":0.3946604114855736,"score_spread":0.3548320040950039,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}