{"id":"W4398143194","doi":"10.1021/acsnano.4c00182","title":"Mechanisms and Barriers in Nanomedicine: Progress in the Field and Future Directions","year":2024,"lang":"en","type":"article","venue":"ACS Nano","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"HORIZON EUROPE Marie Sklodowska-Curie Actions; H2020 Marie Skłodowska-Curie Actions; H2020 European Research Council; U.S. Department of Defense; Skaggs School of Pharmacy and Pharmaceutical Sciences; National Center for Advancing Translational Sciences; Canadian Institutes of Health Research; National Institute of Biomedical Imaging and Bioengineering; National Institute of Allergy and Infectious Diseases; National Heart, Lung, and Blood Institute; Moderna; Natural Sciences and Engineering Research Council of Canada; Networks of Centres of Excellence of Canada; Horizon 2020 Framework Programme; National Institutes of Health; Canada Research Chairs; Cancer Center, University of Colorado; Government of Canada; Deutsche Forschungsgemeinschaft; European Commission; Hebrew University of Jerusalem; H2020 Health; National Institute of Neurological Disorders and Stroke; Bundesministerium für Bildung und Forschung; University of Colorado; National Cancer Institute; Eesti Teadusagentuur","keywords":"Nanomedicine; Context (archaeology); Food and drug administration; Nanotechnology; Engineering ethics; Agency (philosophy); Medicine; Risk analysis (engineering); Political science; Engineering; Nanoparticle; Materials science; Sociology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004930212,0.0000785232,0.00009247194,0.0001019355,0.00006288329,0.00009900578,0.00009703663,0.00005429721,0.00006438838],"category_scores_gemma":[0.0000507827,0.00005187478,0.000009615065,0.0003516448,0.00007514148,0.000154004,0.00004160126,0.0001020659,0.00001136586],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001879217,"about_ca_system_score_gemma":0.00004170447,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006071645,"about_ca_topic_score_gemma":0.000129011,"domain_scores_codex":[0.9992792,0.00007624369,0.0001282231,0.0002125561,0.0001283736,0.0001754093],"domain_scores_gemma":[0.9995814,0.0002143271,0.00001328333,0.0001348629,0.000009649435,0.00004650978],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009930989,0.00009727009,0.007630343,0.0002421498,0.00001244238,0.0004936817,0.0167998,0.000003339606,0.8832262,0.02119128,0.004756335,0.06544784],"study_design_scores_gemma":[0.002835724,0.001102855,0.02343155,0.0008345525,0.0001136273,0.0003132139,0.01621798,0.001156237,0.7772448,0.01478566,0.1609913,0.0009724456],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9819506,0.007170923,0.000009614324,0.009996384,0.000536205,0.0001818451,0.000005195508,0.00004325182,0.0001059819],"genre_scores_gemma":[0.9986193,0.0002915167,0.0001811408,0.0007307378,0.00008171792,0.00005156679,7.57942e-7,0.000006913115,0.00003638387],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.156235,"threshold_uncertainty_score":0.2115392,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005185613389146324,"score_gpt":0.24127836349783,"score_spread":0.2360927501086836,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}