{"id":"W4398147758","doi":"10.1016/s1474-4422(24)00223-0","title":"Amyotrophic lateral sclerosis: a lesson in translation","year":2024,"lang":"en","type":"article","venue":"The Lancet Neurology","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Trinity College","funders":"","keywords":"Amyotrophic lateral sclerosis; SOD1; Medicine; Riluzole; Frontotemporal dementia; Clinical trial; C9orf72; Neuroscience; Physical medicine and rehabilitation; Disease; Dementia; Oncology; Internal medicine; Psychology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0188648,0.001575649,0.002471206,0.002317114,0.001946098,0.007277869,0.002877866,0.01790745,0.01651043],"category_scores_gemma":[0.06550447,0.0007220598,0.001441926,0.001600702,0.01184655,0.01499685,0.004712884,0.03384311,0.01269108],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.005158307,"about_ca_system_score_gemma":0.008970372,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01062853,"about_ca_topic_score_gemma":0.01008802,"domain_scores_codex":[0.9918907,0.002790465,0.001405802,0.0009587003,0.002361518,0.0005928565],"domain_scores_gemma":[0.9436074,0.03394205,0.001517816,0.003515912,0.01378364,0.003633132],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001234634,0.000044978,0.0001794789,0.001327844,0.00004064326,0.0002826774,0.0006525784,0.000120707,0.000173294,0.0342114,0.9096211,0.05322185],"study_design_scores_gemma":[0.0001797457,0.00005152958,0.0004946472,0.002479171,0.00003892522,0.0003324448,0.0007261038,0.00009051809,0.00009283439,0.05291499,0.9425319,0.00006726104],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0001412927,0.09198916,0.00050537,0.7611792,0.1394849,0.000009748761,0.0001405872,0.00006950438,0.006480232],"genre_scores_gemma":[0.007321806,0.1149028,0.001782157,0.5812688,0.2827568,0.0000733565,0.0002165706,0.0002431581,0.0114346],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.0188648,"threshold_uncertainty_score":0.09976786,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1205244729121443,"score_gpt":0.3391764895561311,"score_spread":0.2186520166439869,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}