{"id":"W4398147835","doi":"10.1016/s1474-4422(24)00134-0","title":"Safety and efficacy of arimoclomol in patients with early amyotrophic lateral sclerosis (ORARIALS-01): a randomised, double-blind, placebo-controlled, multicentre, phase 3 trial","year":2024,"lang":"en","type":"article","venue":"The Lancet Neurology","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":false,"ca_institutions":"London Health Sciences Centre; Health Sciences Centre; Western University; Sunnybrook Health Science Centre; Montreal Neurological Institute and Hospital","funders":"","keywords":"Amyotrophic lateral sclerosis; Medicine; Placebo; Double blind; Physical therapy; Clinical trial; Physical medicine and rehabilitation; Internal medicine; Alternative medicine; Pathology; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001741631,0.001891425,0.003293444,0.0003591772,0.0005196763,0.001216635,0.001237362,0.002320164,0.005412539],"category_scores_gemma":[0.001505246,0.0006554142,0.002200826,0.0003394998,0.001226967,0.001175093,0.0004158169,0.003468421,0.001200187],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007308219,"about_ca_system_score_gemma":0.00103401,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001396367,"about_ca_topic_score_gemma":0.003139936,"domain_scores_codex":[0.9994358,0.0002664455,0.00003264377,0.0001063551,0.00004450858,0.000114096],"domain_scores_gemma":[0.9992084,0.0002377613,0.0001722881,0.00005657071,0.00004858706,0.0002765063],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9808912,0.002489603,0.0006541231,0.000638162,0.0009887804,0.00005775226,0.00006091658,0.0001616656,0.002335161,0.00008073084,0.0008486504,0.01079329],"study_design_scores_gemma":[0.9652905,0.03106497,0.002423655,0.00002890785,0.0003888599,0.00003180374,0.00002345995,0.0001774049,0.0001468696,0.00008061849,0.0003276145,0.00001540797],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869644,0.007026311,0.000366421,0.0008104417,0.0005021265,0.001256394,0.0009717035,0.0001509707,0.001951289],"genre_scores_gemma":[0.9893436,0.002713244,0.0007573105,0.001390688,0.0004529797,0.001669917,0.001024098,0.00002794273,0.002620228],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005412539,"threshold_uncertainty_score":0.01810676,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04554186283464148,"score_gpt":0.3116773344806093,"score_spread":0.2661354716459678,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}