{"id":"W4398154122","doi":"10.1101/2022.12.28.522091","title":"Adaptation of redox metabolism in drug-tolerant persister cells is a vulnerability to prevent relapse in pancreatic cancer","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Crandall University","funders":"","keywords":"Adaptation (eye); Vulnerability (computing); Pancreatic cancer; Drug metabolism; Drug; Cancer; Biology; Pharmacology; Medicine; Internal medicine; Neuroscience; Computer science; Computer security","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001091213,0.0001717344,0.0003111835,0.0001642077,0.0001426201,0.0003176689,0.0001313824,0.0002383444,0.001004422],"category_scores_gemma":[0.0001160599,0.00008002907,0.0002684357,0.0001257769,0.0001289839,0.0001936824,0.0001985237,0.0005386408,0.0001912983],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000149385,"about_ca_system_score_gemma":0.0001073479,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001602259,"about_ca_topic_score_gemma":0.0002202363,"domain_scores_codex":[0.9999207,0.00001046325,0.000008808052,0.00002528644,0.00001863497,0.00001607954],"domain_scores_gemma":[0.9999031,0.00001057502,0.00003261644,0.00001713601,0.00001337914,0.00002324333],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001510638,0.00004801088,0.001515942,0.00004482782,0.000007678642,0.00006924698,0.00003135335,0.00005326177,0.994655,0.00004473335,0.00004446213,0.003334445],"study_design_scores_gemma":[0.00002550135,0.002342949,0.04914531,0.00002195044,0.0000637921,0.001027752,0.0002233801,0.000970279,0.940691,0.0001904758,0.00528725,0.00001043373],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996478,0.001443606,0.001381586,0.00006769476,0.00001741559,0.00001808594,0.0001918813,0.00006155102,0.0003400941],"genre_scores_gemma":[0.9979458,0.0004739442,0.0005122672,0.00003859024,0.000006140532,0.00002593761,0.0002380034,0.00001028328,0.0007488691],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001004422,"threshold_uncertainty_score":0.003360152,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01281688147435066,"score_gpt":0.2399746826236514,"score_spread":0.2271578011493007,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}