{"id":"W4398155697","doi":"10.1136/bmjopen-2024-085272","title":"Low-dose naltrexone for post-COVID fatigue syndrome: a study protocol for a double-blind, randomised trial in British Columbia","year":2024,"lang":"en","type":"article","venue":"BMJ Open","topic":"Fibromyalgia and Chronic Fatigue Syndrome Research","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; Fraser Health; B.C. Women's Hospital & Health Centre; BC Children's Hospital; Women's Health Research Institute; University of British Columbia","funders":"BCCDC Foundation for Public Health; British Columbia Centre for Disease Control; Canadian Institutes of Health Research; Ministry of Health, British Columbia; Michael Smith Health Research BC; Health Canada; St. Paul's Foundation","keywords":"Medicine; Placebo; Naltrexone; Chronic fatigue syndrome; Randomized controlled trial; Clinical trial; Physical therapy; Internal medicine; Opioid; Alternative medicine; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0152583,0.0044246,0.007957443,0.001143139,0.002809854,0.002451071,0.003128554,0.005319446,0.04247624],"category_scores_gemma":[0.01165154,0.002299387,0.002991261,0.001951102,0.002589071,0.001597158,0.001226068,0.003874861,0.007741873],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.006909288,"about_ca_system_score_gemma":0.02263733,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.03114951,"about_ca_topic_score_gemma":0.07508215,"domain_scores_codex":[0.9927934,0.003943316,0.0005523351,0.0007957016,0.0006147436,0.001300505],"domain_scores_gemma":[0.9949613,0.0009854982,0.0008976226,0.0005917801,0.00123854,0.001325279],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9470999,0.009513118,0.0005354194,0.007751193,0.0007963963,0.0002025221,0.0003286045,0.001028805,0.002185962,0.001046571,0.009228682,0.02028276],"study_design_scores_gemma":[0.9669291,0.0195469,0.001918641,0.000780578,0.0004043347,0.00002967213,0.00005360625,0.0006014793,0.0002015122,0.0004830328,0.009001864,0.00004929315],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.01540447,0.001080165,0.001362354,0.0005276388,0.0004445111,0.9764117,0.001940998,0.0001565915,0.002671573],"genre_scores_gemma":[0.02421259,0.0008353402,0.003148356,0.0006772508,0.0001366061,0.9672294,0.0004818702,0.00001368736,0.003265007],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.9688505,"threshold_uncertainty_score":0.1420972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.171790177029394,"score_gpt":0.4833714490156336,"score_spread":0.3115812719862396,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}