{"id":"W4398161840","doi":"10.1016/j.celrep.2024.114261","title":"Critical roles of the miR-17∼92 family in thymocyte development, leukemogenesis, and autoimmunity","year":2024,"lang":"en","type":"article","venue":"Cell Reports","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Hospital; University of Toronto; Sunnybrook Health Science Centre; SKiN Health","funders":"Natural Science Foundation of Hunan Province; Shaanxi Normal University; School of Life Sciences and Biotechnology Division of Life Sciences, Korea University; National Natural Science Foundation of China","keywords":"Thymocyte; Dicer; Biology; microRNA; Cancer research; Leukemia; Autoimmunity; Inflammation; Immunology; Chronic lymphocytic leukemia; PI3K/AKT/mTOR pathway; T-cell receptor; Transgene; Signal transduction; Cell biology; T cell; Immune system; Genetics; RNA interference; RNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001983591,0.0003625533,0.0001767775,0.000193131,0.0002381722,0.0004224324,0.0001222692,0.0001758577,0.001087427],"category_scores_gemma":[0.0001620044,0.0001277147,0.0001437225,0.0001026611,0.0002817755,0.0002190831,0.0002846124,0.0003716644,0.0004008999],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001839576,"about_ca_system_score_gemma":0.0003199863,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009182245,"about_ca_topic_score_gemma":0.0001367846,"domain_scores_codex":[0.999858,0.00002465963,0.00001263742,0.00003592602,0.0000415211,0.00002721017],"domain_scores_gemma":[0.9998819,0.00001476935,0.00004458007,0.00001191628,0.00001014425,0.00003671448],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001210997,0.0000105984,0.000895433,0.00003304536,0.000006146349,0.00017086,0.0000221106,0.0001292758,0.9934466,0.0009204611,0.00004910554,0.004195219],"study_design_scores_gemma":[0.00001996926,0.0002061321,0.007232243,0.00001297998,0.00003149105,0.001949316,0.00005533866,0.0008017779,0.9753991,0.0003810198,0.01390325,0.000007352344],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9738972,0.01155927,0.008783823,0.0002053749,0.00004417027,0.00001886247,0.0001920564,0.000171532,0.005127742],"genre_scores_gemma":[0.9910869,0.002831368,0.004003284,0.00004731726,0.00001259604,0.00002070008,0.0001862173,0.00003405367,0.001777526],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001087427,"threshold_uncertainty_score":0.003637791,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00943013170013428,"score_gpt":0.2445996401742047,"score_spread":0.2351695084740704,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}