{"id":"W4398179764","doi":"10.1038/s41589-024-01618-0","title":"A chemical probe to modulate human GID4 Pro/N-degron interactions","year":2024,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; Western University; Structural Genomics Consortium; University of Toronto","funders":"Deutsche Forschungsgemeinschaft; Natural Sciences and Engineering Research Council of Canada; Government of Canada; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Degron; Chemical biology; Chemistry; Nanotechnology; Cell biology; Computational biology; Biology; Biochemistry; Materials science; Ubiquitin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001284102,0.0002550446,0.0002125296,0.00007476307,0.00005329338,0.00003951957,0.0003217671,0.0008662832,0.0001214474],"category_scores_gemma":[0.0001722228,0.0002153778,0.000163399,0.0001896194,0.0001097077,0.000004711651,0.000278872,0.0008441511,0.0001247936],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004530531,"about_ca_system_score_gemma":0.00005762452,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005446588,"about_ca_topic_score_gemma":0.000003698774,"domain_scores_codex":[0.9984443,0.00004442926,0.0002449521,0.0007662895,0.00008524401,0.0004148161],"domain_scores_gemma":[0.9993303,0.00002547958,0.00003221106,0.0003494231,0.00007568739,0.0001868784],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006162082,0.00005701124,0.00006286991,0.00004755324,0.00005810428,0.000006375363,0.00003878601,3.431173e-7,0.9842185,0.004261613,0.00688753,0.004299691],"study_design_scores_gemma":[0.0001416437,0.0001085444,0.00001375163,0.00003637393,0.00001347384,0.00005145529,0.000004795609,0.0000188806,0.7799293,0.00216987,0.2172891,0.0002227829],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897273,0.001806801,0.0004670777,0.001822512,0.0005567013,0.0004708348,0.00008796571,0.0001423545,0.004918463],"genre_scores_gemma":[0.9942675,0.00001508207,0.001880881,0.001119553,0.0009681042,0.0001634272,0.0006880567,0.00004025461,0.0008571401],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2104016,"threshold_uncertainty_score":0.8782852,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01306191697096804,"score_gpt":0.3097047860408429,"score_spread":0.2966428690698749,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}