{"id":"W4398185210","doi":"10.1002/hem3.69","title":"Toward a more patient‐centered drug development process in clinical trials for patients with myelodysplastic syndromes/neoplasms (MDS): Practical considerations from the International Consortium for MDS (icMDS)","year":2024,"lang":"en","type":"review","venue":"HemaSphere","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre","funders":"National Cancer Institute","keywords":"Myelodysplastic syndromes; Medicine; Drug development; Clinical trial; Drug; Intensive care medicine; Oncology; Medical physics; Internal medicine; Pharmacology; Bone marrow","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.1706289,0.001264302,0.005645784,0.002705527,0.0008664631,0.009126789,0.004102163,0.007487558,0.003921531],"category_scores_gemma":[0.1665929,0.001004145,0.004243795,0.003363096,0.004093295,0.01242714,0.003007597,0.0163354,0.00195879],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003319123,"about_ca_system_score_gemma":0.02536221,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001413455,"about_ca_topic_score_gemma":0.003062057,"domain_scores_codex":[0.908231,0.0731556,0.008147934,0.002149532,0.007728297,0.0005877166],"domain_scores_gemma":[0.6733712,0.2818648,0.01425107,0.006239533,0.0208269,0.003446524],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0004426307,0.000235826,0.0003437648,0.04880895,0.0005888275,0.0001416724,0.0006604273,0.001079791,0.0004970701,0.04501853,0.04632168,0.8558608],"study_design_scores_gemma":[0.002074908,0.00111233,0.001376512,0.1104192,0.00151831,0.0007298045,0.0006023622,0.001694017,0.000736651,0.06226936,0.8173015,0.0001650273],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003903121,0.8763211,0.01642372,0.09949234,0.002338785,0.001372181,0.0001425126,0.0001567757,0.003362218],"genre_scores_gemma":[0.009781757,0.781853,0.1299947,0.06732142,0.004138789,0.005086059,0.0002106895,0.0001376802,0.00147599],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8293711,"threshold_uncertainty_score":0.9023827,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2713230922332107,"score_gpt":0.483135307900352,"score_spread":0.2118122156671414,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}