{"id":"W4398193540","doi":"10.1016/j.jcyt.2024.03.385","title":"COMPREHENSIVE ASSESSMENT OF PREMANUFACTURE T CELLS IDENTIFIES FUNCTIONAL DEFECTS AMONG NON-RESPONDERS TO CAR T CELL THERAPY","year":2024,"lang":"en","type":"article","venue":"Cytotherapy","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Stem Cell Network; Hôpital Maisonneuve-Rosemont; Université de Montréal","funders":"","keywords":"Cell therapy; CAR T-cell therapy; T cell; Medicine; Cell; Immunology; Biology; Chimeric antigen receptor; Immune system; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003824527,0.0002005434,0.0002879435,0.0007513819,0.0002085782,0.0004428658,0.0002576048,0.0004567383,0.002151968],"category_scores_gemma":[0.0007003843,0.00008926648,0.0001715891,0.0002565117,0.0002503261,0.0001855662,0.0001748075,0.0003371413,0.0004297135],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002129515,"about_ca_system_score_gemma":0.000128557,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00100297,"about_ca_topic_score_gemma":0.0008623468,"domain_scores_codex":[0.999764,0.00003624117,0.00001842968,0.00004132136,0.00007177259,0.00006818317],"domain_scores_gemma":[0.9996949,0.0000954791,0.00007105182,0.00003151035,0.00005788565,0.00004908931],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00272345,0.0002741533,0.2064359,0.00006948239,0.00003875293,0.001363942,0.000484204,0.0002728557,0.7583036,0.0001751815,0.0004806465,0.02937766],"study_design_scores_gemma":[0.00004294837,0.003847333,0.8279117,0.00002035307,0.0001210724,0.006366321,0.001017219,0.001619354,0.1548923,0.0001887792,0.003955701,0.0000168761],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984518,0.0002688161,0.0003774976,0.00002532414,0.000003249962,0.00002567669,0.0001755463,0.00002335347,0.0006488609],"genre_scores_gemma":[0.9985215,0.00009019838,0.0002336834,0.00003071668,0.00000390863,0.00003310153,0.0002754822,0.000007559546,0.0008038681],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002151968,"threshold_uncertainty_score":0.007199049,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03240886436277794,"score_gpt":0.3354163098976238,"score_spread":0.3030074455348458,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}