{"id":"W4398193540","doi":"10.1016/j.jcyt.2024.03.385","title":"COMPREHENSIVE ASSESSMENT OF PREMANUFACTURE T CELLS IDENTIFIES FUNCTIONAL DEFECTS AMONG NON-RESPONDERS TO CAR T CELL THERAPY","year":2024,"lang":"en","type":"article","venue":"Cytotherapy","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Stem Cell Network; Hôpital Maisonneuve-Rosemont; Université de Montréal","funders":"","keywords":"Cell therapy; CAR T-cell therapy; T cell; Medicine; Cell; Immunology; Biology; Chimeric antigen receptor; Immune system; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002980186,0.0003491388,0.0005460187,0.0005253672,0.00008944988,0.0001100198,0.0002036058,0.0001908125,0.006224626],"category_scores_gemma":[0.000005178731,0.00028504,0.0003848457,0.000556369,0.0001886922,0.0001270765,0.00004367073,0.0004810165,0.0001051994],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002394757,"about_ca_system_score_gemma":0.0004036529,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008831399,"about_ca_topic_score_gemma":0.00001406071,"domain_scores_codex":[0.9974888,0.0001306537,0.0003825246,0.0006141134,0.0009255372,0.0004583533],"domain_scores_gemma":[0.9984391,0.000351702,0.00006805384,0.0006144488,0.0002607112,0.0002659459],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000877678,0.0002006734,0.002214982,0.0003276951,0.0004046611,0.00008123604,0.001606479,0.0005509075,0.9732291,0.00002252458,0.01574073,0.004743396],"study_design_scores_gemma":[0.002224011,0.001067035,0.07722749,0.0001960018,0.00003911994,0.00001362064,0.0004828858,0.0005291625,0.8468758,0.00009409375,0.07097396,0.000276824],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892738,0.002093968,0.00215208,0.000396748,0.0008302827,0.001680192,0.0000376296,0.0001329207,0.003402415],"genre_scores_gemma":[0.9715437,0.001014196,0.000427538,0.0008830322,0.0003734189,0.0001165938,0.0000414777,0.0001218893,0.02547814],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1263532,"threshold_uncertainty_score":0.9999602,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03240886436277794,"score_gpt":0.3354163098976238,"score_spread":0.3030074455348458,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}