{"id":"W4398193808","doi":"10.1016/j.jcyt.2024.03.340","title":"MULTIPLEX GENE EDITING IN CAR T CELLS","year":2024,"lang":"en","type":"article","venue":"Cytotherapy","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Stem Cell Network; Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"","keywords":"Multiplex; Gene; Genome editing; Biology; Computational biology; Genetics; CRISPR","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006500633,0.0005514856,0.000476996,0.000385761,0.0003095424,0.001232009,0.0005473266,0.0008288445,0.00389878],"category_scores_gemma":[0.0004925759,0.0002620711,0.0002872794,0.0002755133,0.0004960759,0.0005771248,0.0006241115,0.001217178,0.0006824892],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005000641,"about_ca_system_score_gemma":0.0002427447,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004753776,"about_ca_topic_score_gemma":0.0006361327,"domain_scores_codex":[0.9994352,0.00009424618,0.00002350667,0.0002014107,0.0001316732,0.0001139405],"domain_scores_gemma":[0.9997564,0.00008435443,0.00004597819,0.00005638472,0.00002563535,0.00003129738],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000145783,0.00005754588,0.0001598228,0.00008775535,0.00001584096,0.00009676057,0.00008538756,0.0006549802,0.9818991,0.004411377,0.0003607438,0.01202489],"study_design_scores_gemma":[0.00002041054,0.0002191523,0.0002012356,0.000004557505,0.00001831455,0.0001815366,0.00001587407,0.001992937,0.9916821,0.0003726662,0.005283752,0.000007368032],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.774909,0.005666676,0.1906707,0.0007510348,0.000365772,0.0005281311,0.0006713009,0.001738745,0.02469858],"genre_scores_gemma":[0.9625041,0.0009235743,0.02453135,0.0001273404,0.00004821447,0.0001914573,0.0001773873,0.0001081391,0.01138844],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00389878,"threshold_uncertainty_score":0.01304269,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03450811823970933,"score_gpt":0.336595826094958,"score_spread":0.3020877078552487,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}