{"id":"W4398193808","doi":"10.1016/j.jcyt.2024.03.340","title":"MULTIPLEX GENE EDITING IN CAR T CELLS","year":2024,"lang":"en","type":"article","venue":"Cytotherapy","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Stem Cell Network; Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"","keywords":"Multiplex; Gene; Genome editing; Biology; Computational biology; Genetics; CRISPR","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003574191,0.0001476065,0.0002434651,0.0002740596,0.00003066464,0.00005388083,0.0001022047,0.0001053258,0.005316969],"category_scores_gemma":[0.00001795237,0.0001286443,0.000118317,0.0004291925,0.0000630057,0.0000617205,0.00001868699,0.0003702127,0.0003115085],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001960842,"about_ca_system_score_gemma":0.0001235325,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001245895,"about_ca_topic_score_gemma":0.00003671928,"domain_scores_codex":[0.9986869,0.00004997422,0.0002201569,0.0003417487,0.0003164335,0.0003848056],"domain_scores_gemma":[0.9993969,0.0001246171,0.00001516909,0.000305569,0.00003839766,0.0001193881],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001232788,0.00005786858,0.001687672,0.00007368514,0.00005259108,0.0004078787,0.001020545,0.0000159063,0.9325598,0.00004035077,0.002214377,0.06174606],"study_design_scores_gemma":[0.002198218,0.0002336087,0.002252243,0.0002069865,0.00001016722,0.00007006066,0.0001741006,0.004743086,0.6996014,0.0001172959,0.2902096,0.0001832637],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986338,0.003901285,0.000260794,0.001325711,0.0006549852,0.0006039353,0.00001230664,0.0002104589,0.006692539],"genre_scores_gemma":[0.9703492,0.001316894,0.001185136,0.0008638742,0.002118236,0.00006693489,0.00002028776,0.0001221988,0.02395725],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2879952,"threshold_uncertainty_score":0.9955923,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03450811823970933,"score_gpt":0.336595826094958,"score_spread":0.3020877078552487,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}