{"id":"W4398193841","doi":"10.1016/j.jcyt.2024.03.414","title":"AN INDUCIBLE LUMINESCENT SYSTEM TO HIGHLIGHT PARKINSON'S DISEASE RISK GENES IN INDUCED PLURIPOTENT STEM CELLS AND DOPAMINERGIC NEURONS","year":2024,"lang":"en","type":"article","venue":"Cytotherapy","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Health Canada","funders":"","keywords":"Induced pluripotent stem cell; Dopaminergic; Parkinson's disease; Stem cell; Human Induced Pluripotent Stem Cells; Neuroscience; Biology; Gene; Disease; Cell biology; Medicine; Genetics; Dopamine; Pathology; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003028776,0.0002963397,0.0002360061,0.0002586528,0.00008769456,0.0001567176,0.0003151464,0.0001447291,0.000007750252],"category_scores_gemma":[0.000005328191,0.0002618885,0.00008008536,0.0003318552,0.0000452582,0.00001356225,0.0001097127,0.0001797429,0.00003706506],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007896146,"about_ca_system_score_gemma":0.0001379046,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001106714,"about_ca_topic_score_gemma":0.00007929861,"domain_scores_codex":[0.9976901,0.0002679789,0.0002908604,0.0009899701,0.0002792941,0.0004818406],"domain_scores_gemma":[0.99872,0.00002029928,0.00004482223,0.0006828857,0.00004957569,0.0004824147],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002235917,0.0001216357,0.006480336,0.0001755192,0.00004245426,0.0002029149,0.00009713906,0.0003330713,0.9831167,0.00004296559,0.0003530465,0.008810611],"study_design_scores_gemma":[0.001197869,0.0008810125,0.02273356,0.0002243965,0.00003389028,0.00003012994,0.0002702249,0.004831557,0.822253,0.000006462221,0.1468495,0.0006883853],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915772,0.006547531,0.0002058878,0.0003570392,0.000395786,0.0006965586,0.00009403453,0.00006738195,0.00005857095],"genre_scores_gemma":[0.9958369,0.002852728,0.00009195599,0.000137715,0.0003123863,0.0001409429,0.000029873,0.00008039298,0.0005171497],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1608637,"threshold_uncertainty_score":0.9999833,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01352728487428649,"score_gpt":0.2601505940332131,"score_spread":0.2466233091589266,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}