{"id":"W4398193841","doi":"10.1016/j.jcyt.2024.03.414","title":"AN INDUCIBLE LUMINESCENT SYSTEM TO HIGHLIGHT PARKINSON'S DISEASE RISK GENES IN INDUCED PLURIPOTENT STEM CELLS AND DOPAMINERGIC NEURONS","year":2024,"lang":"en","type":"article","venue":"Cytotherapy","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Health Canada","funders":"","keywords":"Induced pluripotent stem cell; Dopaminergic; Parkinson's disease; Stem cell; Human Induced Pluripotent Stem Cells; Neuroscience; Biology; Gene; Disease; Cell biology; Medicine; Genetics; Dopamine; Pathology; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005201458,0.0004915735,0.0002331876,0.000385825,0.0002208899,0.0004824442,0.0004476172,0.000494922,0.001919356],"category_scores_gemma":[0.0002452699,0.0002529906,0.000327124,0.0002109118,0.0003043225,0.0003259681,0.0004573986,0.0009375353,0.0004662999],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005102448,"about_ca_system_score_gemma":0.0003608401,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000430941,"about_ca_topic_score_gemma":0.0006898485,"domain_scores_codex":[0.9997618,0.00006164535,0.0000161508,0.00006696264,0.00005759958,0.00003588787],"domain_scores_gemma":[0.9998536,0.00004851913,0.00003561584,0.00001885058,0.00002172747,0.00002165529],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003376109,0.00002176365,0.00005983392,0.00003780652,0.000004043624,0.0000280155,0.00001354915,0.0000697984,0.9972546,0.0006670002,0.0001039282,0.001706075],"study_design_scores_gemma":[0.00001417907,0.00007684161,0.0002287683,0.000005179911,0.000014987,0.00007636741,0.000006937359,0.0006396132,0.9961568,0.00006298038,0.002712881,0.000004585026],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7058493,0.004391571,0.2744949,0.0009491932,0.0003513254,0.0004453011,0.001015238,0.001460053,0.01104324],"genre_scores_gemma":[0.9044243,0.00240388,0.07792281,0.0004497575,0.0000470491,0.0004030839,0.001115987,0.0002234881,0.01300971],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001919356,"threshold_uncertainty_score":0.00642091,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01352728487428649,"score_gpt":0.2601505940332131,"score_spread":0.2466233091589266,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}