{"id":"W4398193851","doi":"10.1016/j.jcyt.2024.03.246","title":"FROM AUTOLOGOUS CELL BANKING TO ALLOGENEIC CELL THERAPY MANUFACTURING: DEVELOPING A CMC STRATEGY FOR THE PRODUCTION OF A GMP-COMPLIANT MSC-BASED THERAPY","year":2024,"lang":"en","type":"article","venue":"Cytotherapy","topic":"3D Printing in Biomedical Research","field":"Engineering","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"","keywords":"Cell therapy; Production (economics); Cell; Business; Medicine; Chemistry; Economics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006041435,0.0003187712,0.0003089408,0.0002346595,0.0001344596,0.0001465529,0.0005904003,0.0001606373,0.0002205133],"category_scores_gemma":[0.00002391119,0.0002245888,0.0001682626,0.0003737961,0.00009422297,0.00006655936,0.0000252937,0.0003163998,0.00003551579],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001539035,"about_ca_system_score_gemma":0.0002016584,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008516009,"about_ca_topic_score_gemma":0.00000981713,"domain_scores_codex":[0.9980446,0.00006982999,0.0004111048,0.0005124297,0.0004067721,0.0005553049],"domain_scores_gemma":[0.9984598,0.0007946703,0.00004770471,0.0005302358,0.00007125167,0.00009632076],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001956119,0.00006902185,0.00005715488,0.0002750772,0.0002021365,0.000008541964,0.001355926,0.02676656,0.7002506,0.0000614515,0.001861925,0.268896],"study_design_scores_gemma":[0.0005566159,0.0002054886,0.001289238,0.0001701438,0.00000750771,0.000001953289,0.0000791943,0.01651024,0.9206871,0.0008403549,0.0593603,0.0002918837],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.876617,0.01034406,0.1076897,0.001686615,0.001258892,0.001631011,0.00003049017,0.0005483635,0.0001937865],"genre_scores_gemma":[0.9876881,0.001628145,0.009243687,0.0002596131,0.0005045157,0.0003397815,0.00001472908,0.0001392707,0.0001822119],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2686041,"threshold_uncertainty_score":0.9158466,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05756119908121679,"score_gpt":0.3109181282304168,"score_spread":0.2533569291492,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}