{"id":"W4398193851","doi":"10.1016/j.jcyt.2024.03.246","title":"FROM AUTOLOGOUS CELL BANKING TO ALLOGENEIC CELL THERAPY MANUFACTURING: DEVELOPING A CMC STRATEGY FOR THE PRODUCTION OF A GMP-COMPLIANT MSC-BASED THERAPY","year":2024,"lang":"en","type":"article","venue":"Cytotherapy","topic":"3D Printing in Biomedical Research","field":"Engineering","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"","keywords":"Cell therapy; Production (economics); Cell; Business; Medicine; Chemistry; Economics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008020782,0.0005780961,0.0003666341,0.0006998699,0.0003992424,0.001751376,0.0004986635,0.0009435047,0.001252147],"category_scores_gemma":[0.0007674232,0.0002533921,0.0003580404,0.0004923243,0.00061451,0.0006727589,0.0009398265,0.001286081,0.001184246],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005107587,"about_ca_system_score_gemma":0.0008533563,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006543211,"about_ca_topic_score_gemma":0.001010686,"domain_scores_codex":[0.9995344,0.00007788836,0.00004344236,0.00008470212,0.0002172417,0.00004232169],"domain_scores_gemma":[0.9995285,0.00009835901,0.0001018381,0.00008089002,0.0001398797,0.00005049538],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003743024,0.00004636737,0.0002530745,0.0001164282,0.000006514519,0.0001823523,0.0001148576,0.000687991,0.9775636,0.002357892,0.0001975218,0.01843608],"study_design_scores_gemma":[0.000005756415,0.0001230174,0.0004117718,0.00003603621,0.00001698569,0.0003632654,0.00004705265,0.002607474,0.9875257,0.0007441164,0.008109363,0.000009528933],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.4179409,0.009277082,0.5407287,0.001882076,0.000413121,0.0009103718,0.000468252,0.0006258439,0.02775364],"genre_scores_gemma":[0.7527246,0.008459474,0.2289716,0.001081621,0.0001221743,0.0003689455,0.0004618403,0.0001942853,0.007615476],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001751376,"threshold_uncertainty_score":0.004241884,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05756119908121679,"score_gpt":0.3109181282304168,"score_spread":0.2533569291492,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}